CHRM1 and RGS7

Number of citations of the paper that reports this interaction (PubMedID 19182865)
55

Data Source:
BioGRID (pull down)

		CHRM1	RGS7
Description		cholinergic receptor muscarinic 1	regulator of G protein signaling 7
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Asymmetric Synapse Presynaptic Membrane Axon Terminus Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Cholinergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Presynaptic Membrane Neuron Projection Dendrite Terminus Postsynaptic Membrane Cell Tip Presynapse Glutamatergic Synapse
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Nervous System Development Regulation Of Locomotion Positive Regulation Of Monoatomic Ion Transport Saliva Secretion Cognition Regulation Of Postsynaptic Membrane Potential Regulation Of Glial Cell Proliferation Positive Regulation Of Intracellular Protein Transport Acetylcholine Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Cevimeline Tramadol Trospium Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Promazine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Amoxapine Cinnarizine Atropine Nicardipine Pirenzepine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupentixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Ketamine Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Staurosporine Acetylcholine Arecoline Mepenzolate NGX267 ALKS 27 Norclozapine Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Pyrantel Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Urate levels ( 31578528)	Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)
Interacting Genes		5 interacting genes: CDC14A GNAI2 GPRASP1 GPRASP2 RGS7	16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		1128	6000
HPRD ID		00338	03948
Ensembl ID		ENSG00000168539	ENSG00000182901
Uniprot IDs		P11229 Q53XZ3	A0A8I5KUA7 A0A8I5KXW5 A0A8I5KZ50 A0A8I5QJU0 B7Z257 P49802
PDB IDs		5CXV 6OIJ 6WJC 6ZFZ 6ZG4 6ZG9	2A72 2D9J 7EWP 7EWR 7SHF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Receptor Catabolic Process Kinociliary Basal Body Negative Regulation Of Signal Transduction Purinergic Nucleotide Receptor Signaling Pathway Guanyl Nucleotide Binding Regulation Of Urine Volume Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Negative Regulation Of Cell Communication Cell Division G Protein-coupled Adenosine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cytosol Cell Tip Dendrite Terminus G-protein Beta-subunit Binding Kinocilium Stereocilium Tip Regulation Of Exit From Mitosis Receptor Catabolic Process Dendrite Gamma-aminobutyric Acid Signaling Pathway Regulation Of Superoxide Metabolic Process G-protein Alpha-subunit Binding Hematopoietic Stem Cell Homeostasis	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex G Protein-coupled Acetylcholine Receptor Activity Guanyl Nucleotide Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Postsynaptic Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Regulation Of Protein Transport Dendrite G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Establishment Of Protein Localization GTPase Activity Regulation Of Transport Regulation Of Insulin Secretion G Protein-coupled Receptor Binding Synapse Regulation Of Peptide Hormone Secretion Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Protein Secretion Negative Regulation Of Protein Transport Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Ciliary Basal Body Regulation Of Secretion By Cell Negative Regulation Of Peptide Secretion Regulation Of Protein Localization Saliva Secretion Trans-synaptic Signaling Synaptic Signaling Regulation Of Secretion GTP Binding Negative Regulation Of Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality G Protein Activity
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