CHRM1 and GPRASP1

Number of citations of the paper that reports this interaction (PMID 15452121)
38

Data Source:
HPRD (in vitro)

		CHRM1	GPRASP1
Gene Name		cholinergic receptor, muscarinic 1	G protein-coupled receptor associated sorting protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Cytoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Drug Binding G-protein Coupled Acetylcholine Receptor Activity	Protein Binding
	Biological Process	Cellular Protein Modification Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Synaptic Transmission Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Locomotion Positive Regulation Of Ion Transport Saliva Secretion Cognition Positive Regulation Of Intracellular Protein Transport	Endosome To Lysosome Transport G-protein Coupled Receptor Catabolic Process
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Cevimeline Succinylcholine Trospium Citalopram Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Atropine Nicardipine Pirenzepine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Cryptenamine Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupenthixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrrolate Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Arecoline Mepenzolate Fesoterodine Aclidinium
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDC14A GNAI2 GPRASP1 GPRASP2	47 interactors: ADRB1 ADRB2 AGTR1 ATXN7 C8orf33 CALCR CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRIP1 CXCR2 F2R F2RL1 GLP1R GLYAT GRM1 GRM5 GRM8 HGH1 HMOX2 HTR7 LAMTOR5 LRP2 MAP7D1 MLNR MTF2 OFD1 OPRD1 OPRK1 OPRL1 OPRM1 OXTR PBK PER1 PFDN1 SNAPIN STMN2 TAC3 TACR1 TACR2 TACR3 TBXA2R TFG TRAF4 VIPR1
Entrez ID		1128	9737
HPRD ID		00338	02333
Ensembl ID		ENSG00000168539	ENSG00000198932
Uniprot IDs		P11229 Q53XZ3	Q5JY77
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Catabolic Process Cell Division Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Adenylate Cyclase Activity Cell Proliferation Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Endosome To Lysosome Transport Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Lysosomal Transport Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Activation Of MAPKK Activity Cell Cycle Vacuolar Transport Receptor Metabolic Process Regulation Of CAMP Biosynthetic Process	G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Cytosolic Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Response To Stimulus Cellular Metal Ion Homeostasis Cell-cell Signaling Positive Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Signaling Signal Transduction Metal Ion Homeostasis Cell Communication Blood Circulation Cellular Chemical Homeostasis Ion Homeostasis Response To Stimulus Neuropeptide Signaling Pathway Regulation Of Muscle Contraction G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Homeostasis Chemical Homeostasis Regulation Of Blood Pressure Tachykinin Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Opioid Receptor Signaling Pathway Regulation Of Vasoconstriction Positive Regulation Of Uterine Smooth Muscle Contraction Neurological System Process Homeostatic Process Regulation Of Cellular Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Blood Pressure Behavior Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Regulation Of Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of CAMP Metabolic Process Response To Abiotic Stimulus Regulation Of Adenylate Cyclase Activity
Tagcloud ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi
Tagcloud (Difference) ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi
Tagcloud (Intersection) ?