CHRM1 and CDC14A

Number of citations of the paper that reports this interaction (PMID 22117071)
8

Data Source:
BioGRID (enzymatic study)

		CHRM1	CDC14A
Gene Name		cholinergic receptor, muscarinic 1	cell division cycle 14A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Drug Binding G-protein Coupled Acetylcholine Receptor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Cellular Protein Modification Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Synaptic Transmission Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Locomotion Positive Regulation Of Ion Transport Saliva Secretion Cognition Positive Regulation Of Intracellular Protein Transport	Cell Cycle Cell Proliferation Peptidyl-tyrosine Dephosphorylation Cell Division
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of mitotic cell cycle Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs		Cevimeline Succinylcholine Trospium Citalopram Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Atropine Nicardipine Pirenzepine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Cryptenamine Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupenthixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrrolate Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Arecoline Mepenzolate Fesoterodine Aclidinium
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDC14A GNAI2 GPRASP1 GPRASP2	8 interactors: BRAP CDC25B CDC6 CHRM1 FZR1 KIF20A POLR2A TP53
Entrez ID		1128	8556
HPRD ID		00338	04614
Ensembl ID		ENSG00000168539	ENSG00000079335
Uniprot IDs		P11229 Q53XZ3	F5H7B3 Q59EF4 Q9UNH5
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Catabolic Process Cell Division Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Adenylate Cyclase Activity Cell Proliferation Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Endosome To Lysosome Transport Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Lysosomal Transport Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Activation Of MAPKK Activity Cell Cycle Vacuolar Transport Receptor Metabolic Process Regulation Of CAMP Biosynthetic Process	Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Mitotic Cell Cycle Regulation Of Cell Cycle Cell Division Cell Cycle Process Regulation Of Cell Cycle Process Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Proliferation Cell Cycle Checkpoint Regulation Of Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of DNA Replication Mitotic Nuclear Division Regulation Of Cytokinesis DNA Metabolic Process Regulation Of Mitotic Cell Cycle Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Negative Regulation Of Macromitophagy Transcription, RNA-templated Oligodendrocyte Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Positive Regulation Of Cell Division DNA Repair Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway DNA Damage Checkpoint Cell Proliferation Traversing Start Control Point Of Mitotic Cell Cycle Organelle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Positive Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Mitochondrial DNA Repair Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Positive Regulation Of Protein Modification Process
Tagcloud ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi	adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Difference) ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi	adhesion agilent bioinformatics cdkn1c cdkn2a clustering col6a3 ctnna3 cycles david differentially distinctly dysregulated experiment focal folds go hoxb4 hyperplastic itgb6 oligonucletide pairs regulated repeating resources scar scars tgfbeta1 twice
Tagcloud (Intersection) ?