CHRM1 and GPRASP2

Number of citations of the paper that reports this interaction (PMID 15086532)
18

Data Source:
HPRD (in vitro)

		CHRM1	GPRASP2
Gene Name		cholinergic receptor, muscarinic 1	G protein-coupled receptor associated sorting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Cytoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Drug Binding G-protein Coupled Acetylcholine Receptor Activity	Beta-amyloid Binding
	Biological Process	Cellular Protein Modification Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Synaptic Transmission Nervous System Development Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Locomotion Positive Regulation Of Ion Transport Saliva Secretion Cognition Positive Regulation Of Intracellular Protein Transport
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Cevimeline Succinylcholine Trospium Citalopram Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Atropine Nicardipine Pirenzepine Paroxetine Homatropine Methylbromide Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Cryptenamine Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupenthixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrrolate Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Arecoline Mepenzolate Fesoterodine Aclidinium
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CDC14A GNAI2 GPRASP1 GPRASP2	25 interactors: ADRB1 ARHGEF6 BARD1 BZRAP1 C6orf165 CALCR CBX8 CHRM1 CHRM2 DISC1 FRAT1 HAP1 HRH2 HTR7 HTT KIAA1377 LOC149950 LRIF1 MYOT PTN RPS6KA5 STMN2 TCF25 TXN TXN2
Entrez ID		1128	114928
HPRD ID		00338	06612
Ensembl ID		ENSG00000168539	ENSG00000158301
Uniprot IDs		P11229 Q53XZ3	B3KW05 Q96D09
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Catabolic Process Cell Division Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Adenylate Cyclase Activity Cell Proliferation Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Endosome To Lysosome Transport Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Lysosomal Transport Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Activation Of MAPKK Activity Cell Cycle Vacuolar Transport Receptor Metabolic Process Regulation Of CAMP Biosynthetic Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Cell-cell Signaling Homeostatic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cation Channel Activity Cell Communication Cellular Response To Stimulus Cognition Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Synaptic Transmission Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Transporter Activity Signaling Positive Regulation Of Ion Transport Cellular Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Ion Transmembrane Transport Regulation Of Cation Channel Activity Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Learning Or Memory Response To Stimulus Glycerol Ether Metabolic Process Cell Redox Homeostasis Memory Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Secretion Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Protein Export From Nucleus Vasoconstriction Developmental Process Vesicle Transport Along Microtubule Positive Regulation Of Adenylate Cyclase Activity Anatomical Structure Development Regulation Of Intracellular Transport Positive Regulation Of Receptor Activity Regulation Of Calcium Ion Transport Single-organism Behavior Response To Reactive Oxygen Species Nervous System Development Positive Regulation Of Signal Transduction
Tagcloud ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi
Tagcloud (Difference) ?		acetylcholine adaptor alanine ap canonical cholinergic clathrin constitutive depended dynamin governed i445a interacted internalization investigations lost machr motif mu2 muscarinic n1e neuroblastoma resembles tryptophan w442a w442y wxxi yxxphi
Tagcloud (Intersection) ?