SLAMF6 and ZAP70

Number of citations of the paper that reports this interaction (PMID 8756661)
35

Data Source:
HPRD (in vivo, in vitro)

		SLAMF6	ZAP70
Gene Name		SLAM family member 6	zeta-chain (TCR) associated protein kinase 70kDa
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Receptor Activity	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process		Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways			TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS		Graves' disease ( 23612905)
Protein-Protein Interactions		4 interactors: PTPN11 PTPN6 SH2D1A ZAP70	58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1
Entrez ID		114836	7535
HPRD ID		05920	01495
Ensembl ID		ENSG00000162739	ENSG00000115085
Uniprot IDs		B4E1U5 Q96DU3	P43403
PDB IDs		2IF7	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Abortive Mitotic Cell Cycle Regulation Of Immune Response Megakaryocyte Development Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Platelet Formation Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Lymphocyte Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation T Cell Costimulation Regulation Of Cell Adhesion Immune System Process Hemopoiesis Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Immune System Development Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Cell Migration Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of T Cell Proliferation Cell Motility	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation
Tagcloud ?		accessory antagonize arsenal associate augments bst2 burst cd4 concomitantly counteract cytopathicity defense downmodulate downmodulates downregulate downregulates evolved hiv humanized impair possesses preference profoundly repertoire spread tethers transplanted virions vpu	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Difference) ?		accessory antagonize arsenal associate augments bst2 burst cd4 concomitantly counteract cytopathicity defense downmodulate downmodulates downregulate downregulates evolved hiv humanized impair possesses preference profoundly repertoire spread tethers transplanted virions vpu	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Intersection) ?