SLAMF6 and CXCL14

Number of citations of the paper that reports this interaction (PubMedID 30204129)
64

Data Source:
BioGRID (pull down)

		SLAMF6	CXCL14
Description		SLAM family member 6	C-X-C motif chemokine ligand 14
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Extracellular Space Golgi Apparatus
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding Chemokine Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity T-helper 17 Cell Lineage Commitment	Chemotaxis Immune Response Signal Transduction Cell-cell Signaling Killing Of Cells Of Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Graves' disease ( 23612905) Multiple sclerosis ( 24076602) Rheumatoid arthritis ( 32723749)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321)
Interacting Genes		11 interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70	28 interacting genes: APP CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL17 CXCL2 CXCL5 CXCL9 F2R GPR85 JMJD6 KLRC1 LMNA PF4 PPBP REL ROBO3 SLAMF6 TEX11 TNFRSF10C TRIM23 XCL1
Entrez ID		114836	9547
HPRD ID		05920	16049
Ensembl ID		ENSG00000162739	ENSG00000145824
Uniprot IDs		B4E1U5 Q96DU3	O95715
PDB IDs		2IF7	2HDL
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Leukocyte Mediated Immunity Immune Effector Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Killing Regulation Of T Cell Proliferation Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Immune System Process Immune System Process Regulation Of T Cell Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Myeloid Cell Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of T Cell Activation Cell Activation Epididymis Development Regulation Of Leukocyte Proliferation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Myeloid Cell Development Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity T Cell Aggregation Mesaxon Protein Dephosphorylation Negative Regulation Of Cell Communication	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Leukocyte Chemotaxis Locomotion Cell Chemotaxis Humoral Immune Response Cytokine Activity Granulocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Leukocyte Migration Myeloid Leukocyte Migration Granulocyte Migration Killing Of Cells Of Another Organism Response To External Biotic Stimulus Response To Other Organism Immune System Process Defense Response Immune Response Inflammatory Response CXCR Chemokine Receptor Binding Chemokine-mediated Signaling Pathway Cell Killing Cell Migration Cell Motility Mononuclear Cell Migration Chemokine Receptor Binding Neutrophil Chemotaxis CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Extracellular Space Response To Stress Neutrophil Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway CXCR3 Chemokine Receptor Binding Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Eosinophil Chemotaxis Extracellular Region Positive Regulation Of Leukocyte Chemotaxis Regulation Of T Cell Migration Positive Regulation Of Mononuclear Cell Migration Eosinophil Migration Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis
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