TWF2 and CHGB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TWF2	CHGB
Gene Name		twinfilin actin-binding protein 2	chromogranin B (secretogranin 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Secretory Granule
	Molecular Function	Actin Monomer Binding Protein Kinase C Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Poly(A) RNA Binding	Hormone Activity Protein Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Sequestering Of Actin Monomers Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		6 interactors: ARHGDIA CHGB FOXJ1 ILK POT1 TERF2IP	31 interactors: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 MARK3 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SGK223 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		11344	1114
HPRD ID		08464	07512
Ensembl ID		ENSG00000247596	ENSG00000089199
Uniprot IDs		Q6IBS0	P05060
PDB IDs		2VAC 2W0I
Enriched GO Terms of Interacting Partners?		Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Establishment Or Maintenance Of Apical/basal Cell Polarity Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Negative Regulation Of Chromosome Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Metabolic Process Regulation Of Cell Adhesion Kidney Morphogenesis Positive Regulation Of DNA Strand Elongation Positive Regulation Of Lung Ciliated Cell Differentiation Central Tolerance Induction Negative Regulation Of DNA Recombination At Telomere Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of Cellular Component Organization Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Negative Regulation Of Cellular Metabolic Process Nephron Development Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Regulation Of Axonogenesis Positive Regulation Of Cell Differentiation Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Organelle Organization Establishment Or Maintenance Of Cell Polarity Glomerular Parietal Epithelial Cell Differentiation Telomere Formation Via Telomerase Negative Regulation Of Cell Migration Regulation Of Chromosome Organization Negative Regulation Of Cell Adhesion Positive Regulation Of Hydrolase Activity Negative Regulation Of Cell Motility Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Movement Protection From Non-homologous End Joining At Telomere Negative Regulation Of Locomotion Protein Localization To Chromosome, Telomeric Region	Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Developmental Growth Cellular Metabolic Process Cellular Component Assembly Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Cell Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Synaptic Transmission Response To Metal Ion Response To Lipid Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cell Development Generation Of Neurons Response To Growth Factor Phosphate-containing Compound Metabolic Process Response To Organic Cyclic Compound Protein Homotetramerization Platelet Activation Positive Regulation Of Metabolic Process Response To Stress Metabolic Process Neurogenesis Response To Organic Substance Positive Regulation Of Lamellipodium Assembly Cellular Process Apoptotic Process Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Defense Response Hemostasis DNA-templated Transcription, Initiation Negative Regulation Of Developmental Growth Response To Wounding Long Term Synaptic Depression Programmed Cell Death Regulation Of Neurogenesis Nucleotide-excision Repair Positive Regulation Of Lamellipodium Organization Negative Regulation Of Growth Cell Death Death Cell Development Regulation Of Protein Import Into Nucleus, Translocation Developmental Process Regulation Of Cell Morphogenesis Response To Inorganic Substance
Tagcloud ?			adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Difference) ?			adjunct aggressiveness atrx avidity cc chga chromogranin classifications cytoplasmic daxx exome fdg germline hippel inherited ki lastly lindau neuroendocrine pnet pnets pten retardation rho subcellular tensin thalassemia vhl von
Tagcloud (Intersection) ?