TWF2 and ARHGDIA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TWF2	ARHGDIA
Gene Name		twinfilin actin-binding protein 2	Rho GDP dissociation inhibitor (GDI) alpha
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Immunological Synapse Cytosol Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Monomer Binding Protein Kinase C Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Poly(A) RNA Binding	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Sequestering Of Actin Monomers Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus	Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Cell Migration Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways			Rho GTPase cycle Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis Axonal growth stimulation Signaling by Rho GTPases p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		6 interactors: ARHGDIA CHGB FOXJ1 ILK POT1 TERF2IP	36 interactors: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B FEN1 HAAO HERPUD1 IKBKG JUP MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2L6 UBE2R2 UFM1 VAV1
Entrez ID		11344	396
HPRD ID		08464	03565
Ensembl ID		ENSG00000247596	ENSG00000141522
Uniprot IDs		Q6IBS0	J3QQX2 J3QW41 P52565
PDB IDs		2VAC 2W0I	1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0
Enriched GO Terms of Interacting Partners?		Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Establishment Or Maintenance Of Apical/basal Cell Polarity Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Negative Regulation Of Chromosome Organization Regulation Of Intracellular Signal Transduction Negative Regulation Of DNA Metabolic Process Regulation Of Cell Adhesion Kidney Morphogenesis Positive Regulation Of DNA Strand Elongation Positive Regulation Of Lung Ciliated Cell Differentiation Central Tolerance Induction Negative Regulation Of DNA Recombination At Telomere Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of Cellular Component Organization Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Negative Regulation Of Cellular Metabolic Process Nephron Development Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Regulation Of Axonogenesis Positive Regulation Of Cell Differentiation Kidney Epithelium Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Regulation Of Organelle Organization Establishment Or Maintenance Of Cell Polarity Glomerular Parietal Epithelial Cell Differentiation Telomere Formation Via Telomerase Negative Regulation Of Cell Migration Regulation Of Chromosome Organization Negative Regulation Of Cell Adhesion Positive Regulation Of Hydrolase Activity Negative Regulation Of Cell Motility Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Negative Regulation Of Cellular Component Movement Protection From Non-homologous End Joining At Telomere Negative Regulation Of Locomotion Protein Localization To Chromosome, Telomeric Region	Response To Stress Response To Stimulus Cellular Response To Stimulus Homeostatic Process Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction Positive Regulation Of Cell Death Signaling Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Component Biogenesis Cell Communication Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Catalytic Activity Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Programmed Cell Death Small GTPase Mediated Signal Transduction Blood Coagulation Regulation Of Telomere Maintenance Hemostasis Response To Abiotic Stimulus Regulation Of Signaling Telomere Maintenance Regulation Of Catalytic Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Lamellipodium Assembly Response To Wounding Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Organic Substance
Tagcloud ?			3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Difference) ?			3p 5p biogenesis bioinformatics biologically compete complementary conversely counterparts e2f6 experimentally hence intermediates mature mere micrornas mir mirna mirnas pipeline precursors pri regulators repression separate serve snai2 untranslated utr
Tagcloud (Intersection) ?