TWF2 and FOXJ1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TWF2	FOXJ1
Name		twinfilin actin binding protein 2	forkhead box J1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Myofibril Lamellipodium Filopodium Growth Cone Stereocilium Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromatin Nucleus
	Molecular Function	RNA Binding Actin Binding Actin Monomer Binding Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Anion Binding Cadherin Binding Actin Filament Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Cell Projection Organization Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Regulation Of Microvillus Length Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Axon Extension Barbed-end Actin Filament Capping Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 ) Schizophrenia ( 23974872 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: COXFA4L3 FAM107A MANF NISCH STAB1	9 novel interactors: ATP10A CD79B CDK3 FBXO22 FKBP1A GATA6 PECAM1 PRKCA SMURF2
Interacting Genes		7 interacting genes: ARHGDIA CEBPA CHGB FOXJ1 ILK POT1 TERF2IP	8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2
Entrez ID		11344	2302
HPRD ID		08464	03798
Ensembl ID		ENSG00000247596	ENSG00000129654
Uniprot IDs		Q6IBS0	Q92949
PDB IDs		2VAC 2W0I	Not available
GO Terms Enriched among Interactors		Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Intracellular Signal Transduction RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glomerular Parietal Epithelial Cell Development Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Central B Cell Tolerance Induction Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Osteoblast Differentiation Response To Vitamin B2 C/EBP Complex Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity CHOP-C/EBP Complex Protein Localization To Cell Cortex DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Intracellular Signaling Cassette Regulation Of Non-canonical NF-kappaB Signal Transduction Telomere Maintenance Positive Regulation Of Chromosome Organization White Fat Cell Proliferation Metanephric Part Of Ureteric Bud Development Regulation Of Telomere Maintenance Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Hemopoiesis Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Ciliary Basal Body Organization Single-stranded Telomeric DNA Binding Telomere Organization	None