TBKBP1 and APBA3

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		TBKBP1	APBA3
Gene Name		TBK1 binding protein 1	amyloid beta (A4) precursor protein-binding, family A, member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Beta-amyloid Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Innate Immune Response	In Utero Embryonic Development Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Multiple sclerosis ( 22190364)
Protein-Protein Interactions		3 interactors: AGO2 APBA3 RB1CC1	6 interactors: APP AZI2 BCR EGFR TANK TBKBP1
Entrez ID		9755	9546
HPRD ID		12239	05038
Ensembl ID		ENSG00000198933	ENSG00000011132
Uniprot IDs		A7MCY6	O96018
PDB IDs			2YT7 2YT8
Enriched GO Terms of Interacting Partners?		MRNA Cleavage Involved In Gene Silencing By MiRNA SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA 3'-end Processing MiRNA Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cell Size RNA Interference Pre-miRNA Processing Regulation Of MRNA 3'-end Processing MRNA Cleavage Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Catabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Autophagic Vacuole Assembly Macroautophagy Gene Silencing By RNA Multicellular Organismal Development	Innate Immune Response Immune System Process I-kappaB Kinase/NF-kappaB Signaling Immune Response Defense Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Regulation Of ERBB Signaling Pathway Tumor Necrosis Factor Production Alkanesulfonate Metabolic Process Cell Activation Neuromuscular Process Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Intracellular Signal Transduction Brain Development Head Development Interferon-alpha Production Collateral Sprouting In Absence Of Injury Regulation Of Immune Response Interleukin-6 Production Activation Of Phospholipase A2 Activity Regulation Of Cell Cycle Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Positive Regulation Of Phospholipase A2 Activity Collateral Sprouting Axon Midline Choice Point Recognition Dendritic Cell Proliferation Central Nervous System Development Response To Cobalamin Response To UV-A Negative Regulation Of Neutrophil Degranulation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Hydrolase Activity Response To Hydroxyisoflavone Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Axon Choice Point Recognition Response To Stimulus Learning Or Memory Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Inflammatory Response Peptidyl-tyrosine Phosphorylation Neurological System Process Positive Regulation Of Cell Cycle Cognition Cell Adhesion
Tagcloud ?		activator ag azacytidine azi2 cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tnfr	a4 additive aging amyloid apbb1 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?		activator ag azacytidine azi2 cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tnfr	a4 additive aging amyloid apbb1 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?