ELL and EAF1

Number of citations of the paper that reports this interaction (PMID 11418481)
20

Data Source:
HPRD (in vivo)

		ELL	EAF1
Gene Name		elongation factor RNA polymerase II	ELL associated factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Speck Transcriptionally Active Chromatin Histone Locus Body	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Speck ELL-EAF Complex
	Molecular Function	Protein Binding Phosphatase Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Phosphatase Activity Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription From RNA Polymerase II Promoter SnRNA Transcription From RNA Polymerase III Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Viral Transcription	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		10 interactors: EAF1 EAF2 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC ZHX1	13 interactors: AES APP BEND7 CEP76 ELL ELL2 HOMER3 MIPOL1 PSME3 SDCBP TFCP2 TFPT ZBTB14
Entrez ID		8178	85403
HPRD ID		02615	12209
Ensembl ID		ENSG00000105656	ENSG00000144597
Uniprot IDs		P55199	B4E3F5 Q96JC9
PDB IDs		2DOA
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Circadian Rhythm Regulation Of RNA Metabolic Process DNA Repair Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Cellular Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Transcription From RNA Polymerase II Promoter Apoptotic Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Cell Death Death Signal Transduction In Response To DNA Damage Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint	SnRNA Transcription From RNA Polymerase II Promoter SnRNA Transcription Gene Expression SnRNA Metabolic Process RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Glutamate Receptor Signaling Pathway Regulation Of Cellular Process DNA-templated Transcription, Elongation Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Anoikis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Negative Regulation Of Canonical Wnt Signaling Pathway SnRNA Transcription From RNA Polymerase III Promoter Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Gene Expression Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Axon Choice Point Recognition Negative Regulation Of Wnt Signaling Pathway Neuron Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Exosomal Secretion
Tagcloud ?		1st backgrounds behaviors concepts confused constructs contexts distinguishable ells english examines examining language learners mothers native pathologizing ratings ses shy shyness socially socioeconomic speakers speaking unsociability unsociable withdrawal withdrawn	5days advance cd71 cd71high coitum counterpart enucleated eryps erythroblasts erythrocyte erythrocytes erythropoiesis esc escs globin hoxb4 klf1 maturational primitive proliferating reflect represented sac segregation switching technical ter119 went yolk
Tagcloud (Difference) ?		1st backgrounds behaviors concepts confused constructs contexts distinguishable ells english examines examining language learners mothers native pathologizing ratings ses shy shyness socially socioeconomic speakers speaking unsociability unsociable withdrawal withdrawn	5days advance cd71 cd71high coitum counterpart enucleated eryps erythroblasts erythrocyte erythrocytes erythropoiesis esc escs globin hoxb4 klf1 maturational primitive proliferating reflect represented sac segregation switching technical ter119 went yolk
Tagcloud (Intersection) ?