ELL and HDAC3

Number of citations of the paper that reports this interaction (PubMedID 36036574)
35

Data Source:
BioGRID (enzymatic study, pull down, affinity chromatography technology)

		ELL	HDAC3
Description		elongation factor for RNA polymerase II	histone deacetylase 3
Image
GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Histone Locus Body	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Phosphatase Binding	Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Hydrolase Activity Deacetylase Activity Enzyme Binding Cyclin Binding Chromatin DNA Binding Protein Lysine Deacetylase Activity Histone Deacetylase Binding GTPase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Ubiquitin-specific Protease Binding
	Biological Process	In Utero Embryonic Development Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Chromatin Organization Transcription By RNA Polymerase II Protein Deacetylation Regulation Of Mitotic Cell Cycle Epidermis Development Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of TOR Signaling Negative Regulation Of Interleukin-1 Production Negative Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Protein Modification Process Regulation Of Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Protein Export From Nucleus Rhythmic Process Spindle Assembly Random Inactivation Of X Chromosome Neural Precursor Cell Proliferation Establishment Of Skin Barrier Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Response To Dexamethasone Negative Regulation Of Ferroptosis Positive Regulation Of Cold-induced Thermogenesis DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Ferroptosis Cornified Envelope Assembly Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs			Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Phenylbutyric acid Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 29059683 23535729) Coronary artery disease ( 29212778) HDL cholesterol levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		13 interacting genes: EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC WEE2-AS1 ZHX1	103 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 CUL4B DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16
Entrez ID		8178	8841
HPRD ID		02615	08950
Ensembl ID		ENSG00000105656	ENSG00000171720
Uniprot IDs		P55199 U3KQ90	O15379
PDB IDs		2DOA	4A69
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Circadian Rhythm Chromatin Remodeling Transcription Elongation By RNA Polymerase II Super Elongation Complex DNA-templated Transcription Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Transcription Elongation Factor Activity Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of RNA Biosynthetic Process Nucleus Promoter-specific Chromatin Binding Chromatin Organization Cellular Response To Parathyroid Hormone Stimulus Nucleobase-containing Compound Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of RNA Metabolic Process Chromatin DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Rhythmic Process Random Inactivation Of X Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Transcription Elongation By RNA Polymerase II Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Elongation Ubiquitin Protein Ligase Binding Regulation Of Telomere Maintenance Regulation Of Gene Expression Negative Regulation Of Small Molecule Metabolic Process Protein Localization To Organelle Regulation Of DNA Replication Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription Elongation Factor Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Histone Deacetylase Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Cell Differentiation Transcription Repressor Complex Transcription Regulator Complex DNA-binding Transcription Factor Binding Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Organization Transcription Coactivator Binding Regulation Of MiRNA Metabolic Process Regulation Of Developmental Process Histone Deacetylase Complex DNA-binding Transcription Factor Activity
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