ELL

Name	elongation factor for RNA polymerase II
Structure
Novel Interactors	1 novel interactors: PRKACA
Interactors	13 interactors: EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC WEE2-AS1 ZHX1
GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Histone Locus Body
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Phosphatase Binding
	Biological Process	In Utero Embryonic Development Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III
Pathways	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
GWAS	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 34315874 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 ) Breast cancer ( 29059683 23535729 ) Coronary artery disease ( 29212778 ) HDL cholesterol levels ( 32203549 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Monocyte count ( 32888494 ) Pulse pressure ( 30224653 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist-hip index ( 34021172 )
Entrez ID	8178
HPRD ID	02615
Ensembl ID	ENSG00000105656
Uniprot IDs	P55199 U3KQ90
PDB IDs	2DOA
GO Terms Enriched among Interactors ?	Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Circadian Rhythm Chromatin Remodeling Transcription Elongation By RNA Polymerase II Super Elongation Complex DNA-templated Transcription Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Transcription Elongation Factor Activity Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of RNA Biosynthetic Process Nucleus Promoter-specific Chromatin Binding Chromatin Organization Cellular Response To Parathyroid Hormone Stimulus Nucleobase-containing Compound Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of RNA Metabolic Process Chromatin DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Rhythmic Process Random Inactivation Of X Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Transcription Elongation By RNA Polymerase II Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Elongation Ubiquitin Protein Ligase Binding Regulation Of Telomere Maintenance Regulation Of Gene Expression Negative Regulation Of Small Molecule Metabolic Process Protein Localization To Organelle Regulation Of DNA Replication Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription Elongation Factor Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome