MAPK7 and PTPRR

Number of citations of the paper that reports this interaction (PubMedID 12042304)
0

Data Source:
HPRD (in vitro, in vivo)

		MAPK7	PTPRR
Description		mitogen-activated protein kinase 7	protein tyrosine phosphatase receptor type R
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	In Utero Embryonic Development Protein Dephosphorylation Signal Transduction Negative Regulation Of Epithelial Cell Migration ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)	Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) HDL cholesterol levels ( 32203549) Influenza A (H1N1) infection ( 26379185) Intraocular pressure ( 29785010) Mild influenza (H1N1) infection ( 26379185) Monobrow ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Uterine fibroids ( 31649266)
Interacting Genes		31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1	27 interacting genes: AATK CNKSR1 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 FGFR4 GABARAPL1 IGF1R INSR KDR LMTK2 MAPK1 MAPK3 MAPK7 MST1R NTRK1 PRKACA PTK7 RET ROR1 ROR2 RYK SNCA TEK
Entrez ID		5598	5801
HPRD ID		03952	04169
Ensembl ID		ENSG00000166484	ENSG00000153233
Uniprot IDs		Q13164	B7Z998 Q15256
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS	2A8B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway ATP Binding Nucleotide Binding Transferase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Autophosphorylation ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Coreceptor Activity Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Animal Organ Development Epidermal Growth Factor Receptor Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion ERBB Signaling Pathway Regulation Of Multicellular Organismal Process Membrane
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