MAPK7 and PTPRR

Number of citations of the paper that reports this interaction (PMID 12042304)
12

Data Source:
HPRD (in vivo, in vitro)

		MAPK7	PTPRR
Gene Name		mitogen-activated protein kinase 7	protein tyrosine phosphatase, receptor type, R
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Extracellular Space Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of CAMP Catabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Stress-activated MAPK Cascade Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	In Utero Embryonic Development Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Homophilic Cell Adhesion
Pathways		Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling to ERK5 ERKs are inactivated Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Refractive error ( 23396134)
Protein-Protein Interactions		27 interactors: ACTN4 APP C5orf30 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL	4 interactors: MAPK1 MAPK3 MAPK7 PRKACA
Entrez ID		5598	5801
HPRD ID		03952	04169
Ensembl ID		ENSG00000166484	ENSG00000153233
Uniprot IDs		Q13164	Q15256 Q7Z2V8
PDB IDs		2Q8Y 4B99 4IC7 4IC8	2A8B
Enriched GO Terms of Interacting Partners?		Response To Fluid Shear Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fluid Shear Stress Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Behavioral Fear Response Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cellular Component Organization Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Proliferation Cardiac Conduction Regulation Of Signal Transduction Cardiovascular System Development Regulation Of RNA Metabolic Process Regulation Of MAPK Cascade Learning Or Memory Anatomical Structure Morphogenesis Signal Transduction Response To Hormone	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Golgi Inheritance Regulation Of Intracellular Transport Toll-like Receptor 4 Signaling Pathway Caveolin-mediated Endocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Toll-like Receptor Signaling Pathway Response To Growth Factor Peptidyl-serine Phosphorylation Regulation Of Golgi Organization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Early Endosome To Late Endosome Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-amino Acid Modification MAPK Cascade Regulation Of Cellular Localization Regulation Of Innate Immune Response JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Activation Of Protein Kinase Activity Growth Hormone Receptor Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Growth Hormone Stimulus Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process
Tagcloud ?			abilities biopsy cervical cin3 colposcopy cytological cytology detecting diagnoses directed fifteen intraepithelial lsil lsils methylated multicenter neoplasias operating pax1 receiver scrapings sensitivities sox1 specificities standardized swabs testing triage znf582
Tagcloud (Difference) ?			abilities biopsy cervical cin3 colposcopy cytological cytology detecting diagnoses directed fifteen intraepithelial lsil lsils methylated multicenter neoplasias operating pax1 receiver scrapings sensitivities sox1 specificities standardized swabs testing triage znf582
Tagcloud (Intersection) ?