MAPK7 and MEF2A

Number of citations of the paper that reports this interaction (PubMedID 9858528)
49

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MAPK7	MEF2A
Description		mitogen-activated protein kinase 7	myocyte enhancer factor 2A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA-templated Transcription Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Mitochondrion Distribution Animal Organ Development Dendrite Morphogenesis Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	ERK/MAPK targets Myogenesis
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1	30 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN GABARAPL2 HAND1 HDAC4 HDAC5 HDAC7 HDAC9 HSF2BP MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		5598	4205
HPRD ID		03952	02807
Ensembl ID		ENSG00000166484	ENSG00000068305
Uniprot IDs		Q13164	A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A0A8I5KVQ4 A8K720 Q02078
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS	1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1 7XUZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Cellular Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Cell Differentiation Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Myotube Differentiation Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Developmental Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Animal Organ Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Protein Lysine Deacetylase Activity Positive Regulation Of Biosynthetic Process Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Heart Development Cell Fate Commitment DNA-binding Transcription Factor Binding Histone Deacetylase Activity Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity Skeletal Muscle Tissue Development Striated Muscle Tissue Development Nucleoplasm Chromatin Striated Muscle Cell Differentiation
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