MAPK7 and GJA1

Number of citations of the paper that reports this interaction (PMID 9535909)
52

Data Source:
HPRD (in vivo, in vitro)

		MAPK7	GJA1
Gene Name		mitogen-activated protein kinase 7	gap junction protein, alpha 1, 43kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Golgi Membrane Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intermediate Filament Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexon Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Contractile Fiber Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding	Signal Transducer Activity Receptor Binding Gap Junction Channel Activity Protein Binding Ion Transmembrane Transporter Activity SH3 Domain Binding PDZ Domain Binding Beta-tubulin Binding Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Scaffold Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Signal Transduction Peptidyl-serine Phosphorylation CAMP-mediated Signaling Cell Differentiation Negative Regulation Of CAMP Catabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Stress-activated MAPK Cascade Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Osteoblast Differentiation In Utero Embryonic Development Neuron Migration Negative Regulation Of Endothelial Cell Proliferation Heart Looping Epithelial Cell Maturation Lens Development In Camera-type Eye Chronic Inflammatory Response Positive Regulation Of Glomerular Filtration Endothelium Development Atrial Ventricular Junction Remodeling Transport Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Adult Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling ATP Transport Gap Junction Assembly Regulation Of Bone Mineralization Positive Regulation Of Insulin Secretion Ion Transmembrane Transport Response To Fluid Shear Stress Embryonic Digit Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Response To Peptide Hormone Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Regulation Of Bone Remodeling Blood Vessel Morphogenesis Neuron Projection Morphogenesis Protein Oligomerization Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Milk Ejection Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Membrane Organization Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process Regulation Of Tight Junction Assembly Positive Regulation Of Behavioral Fear Response
Pathways		Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling to ERK5 ERKs are inactivated Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	c-src mediated regulation of Cx43 function and closure of gap junctions Transport of connexons to the plasma membrane Formation of annular gap junctions Gap junction assembly Transport of connexins along the secretory pathway Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Oligomerization of connexins into connexons Regulation of gap junction activity
Drugs			Carvedilol
Diseases
GWAS			Heart rate ( 23583979) Protein quantitative trait loci ( 18464913) Resting heart rate ( 23183192 20639392)
Protein-Protein Interactions		27 interactors: ACTN4 APP C5orf30 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL	18 interactors: CAV1 CNST CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 NOV PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1
Entrez ID		5598	2697
HPRD ID		03952	00414
Ensembl ID		ENSG00000166484	ENSG00000152661
Uniprot IDs		Q13164	P17302
PDB IDs		2Q8Y 4B99 4IC7 4IC8	2LL2
Enriched GO Terms of Interacting Partners?		Response To Fluid Shear Stress Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Cellular Response To Growth Factor Stimulus Cell Death Death Positive Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fluid Shear Stress Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Behavioral Fear Response Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cellular Component Organization Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Proliferation Cardiac Conduction Regulation Of Signal Transduction Cardiovascular System Development Regulation Of RNA Metabolic Process Regulation Of MAPK Cascade Learning Or Memory Anatomical Structure Morphogenesis Signal Transduction Response To Hormone	Platelet Activation Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Wound Healing Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-serine Phosphorylation Signaling Cell Communication Response To Wounding Intracellular Signal Transduction Regulation Of Cellular Localization Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Immune System Process Protein Phosphorylation Peptidyl-amino Acid Modification Phosphorylation Cell Activation Regulation Of Intracellular Transport Regulation Of Phosphorus Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Signal Transduction Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Cell-cell Signaling Response To Growth Factor Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Cell Cycle Regulation Of MAPK Cascade Regulation Of Protein Transport Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?			14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks
Tagcloud (Difference) ?			14days 1mg 3days alters anthracene antral connexin cx cx37 cx43 cx45 dimethylbenz dmba dosed follicle folliculogenesis gap gja4 gjc1 junction lean obese obesity ovaries ovotoxicity sesame temporally thereafter wks
Tagcloud (Intersection) ?