MAPK7 and MACIR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MAPK7	MACIR
Description		mitogen-activated protein kinase 7	macrophage immunometabolism regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Cytoplasm Cilium Ciliary Transition Zone Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Inflammatory Response Epithelial Cell Migration Negative Regulation Of Epithelial Cell Migration Fibroblast Migration Negative Regulation Of Fibroblast Migration Protein Transport Cell Projection Organization Negative Regulation Of Inflammatory Response Cilium Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644)
Interacting Genes		31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1	5 interacting genes: EXOSC8 MAPK7 MDFI PNMA1 TRAF1
Entrez ID		5598	90355
HPRD ID		03952	12383
Ensembl ID		ENSG00000166484	ENSG00000181751
Uniprot IDs		Q13164	Q96GV9
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process	Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Negative Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Smooth Muscle Cell Apoptotic Process MAP Kinase Activity Cellular Response To Laminar Fluid Shear Stress Thioesterase Binding U5 SnRNA 3'-end Processing Exoribonuclease Complex U1 SnRNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Exosome (RNase Complex) RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Programmed Cell Death Negative Regulation Of Calcium-mediated Signaling Mitogen-activated Protein Kinase Binding Response To Laminar Fluid Shear Stress Calcineurin-NFAT Signaling Cascade SnRNA 3'-end Processing
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