MAPK7 and ELK4

Number of citations: 0 (PubMedID 10473620)
Data Source: HPRD (in vivo, in vitro)

		MAPK7	ELK4
Name		mitogen-activated protein kinase 7	ETS transcription factor ELK4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	None
Drugs		Acetylsalicylic acid Minocycline Colforsin Fostamatinib	None
Diseases		None	Prostate cancer
GWAS		Alzheimer's disease ( 30636644 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: ADI1 FLII MAP2K4 MFAP4 RASGRP1 SREBF1	1 novel interactors: FGFR2
Interacting Genes		31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1	11 interacting genes: BRCA1 FOS ID1 ID2 ID3 MAPK1 MAPK11 MAPK3 MAPK7 MAPK8 SRF
Entrez ID		5598	2005
HPRD ID		03952	02592
Ensembl ID		ENSG00000166484	ENSG00000158711
Uniprot IDs		Q13164	P28324 Q8IXL1
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS	1BC7 1BC8 1HBX 1K6O
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process	MAP Kinase Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lung Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Animal Organ Morphogenesis Cellular Senescence Cell Differentiation Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MAPK Cascade Face Development Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Tumor Necrosis Factor Protein Kinase Activity Hematopoietic Or Lymphoid Organ Development Cellular Response To Oxygen-containing Compound Cellular Response To Nutrient Levels Positive Regulation Of Nucleobase-containing Compound Metabolic Process Heart Development Animal Organ Development Regulation Of Multicellular Organismal Development Response To Cytokine Cellular Developmental Process Nucleoplasm Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Thyroid Gland Development Response To Tumor Necrosis Factor Response To Lipopolysaccharide Astrocyte Differentiation Interleukin-34-mediated Signaling Pathway Response To Growth Factor Regulation Of Cell Differentiation Kinase Activity Cellular Response To Stress Regulation Of DNA-templated Transcription Response To Molecule Of Bacterial Origin Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Regulation Of Osteoblast Differentiation Regulation Of Golgi Inheritance Transcription Regulator Inhibitor Activity