Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
SUPT16H and H2AFX
Number of citations of the paper that reports this interaction (PMID
18406329
)
45
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)
SUPT16H
H2AFX
Gene Name
suppressor of Ty 16 homolog (S. cerevisiae)
H2A histone family, member X
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Poly(A) RNA Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
DNA Replication
DNA Repair
Nucleosome Disassembly
Transcription From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
Gene Expression
Viral Process
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Viral Transcription
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Transcription
HIV Infection
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
RNA Polymerase II Pre-transcription Events
Late Phase of HIV Life Cycle
Pausing and recovery of Tat-mediated HIV elongation
Formation of RNA Pol II elongation complex
HIV elongation arrest and recovery
HIV Life Cycle
Pausing and recovery of HIV elongation
Formation of HIV elongation complex in the absence of HIV Tat
HIV Transcription Elongation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
GTF2E2
H2AFX
H3F3A
HIST1H2AI
MCM3
MCM4
NEK9
PARP1
SREK1
SRPK2
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
11198
3014
HPRD ID
16088
03465
Ensembl ID
ENSG00000092201
ENSG00000188486
Uniprot IDs
Q9Y5B9
P16104
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
DNA Conformation Change
Chromosome Organization
DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Organelle Organization
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Heterocycle Metabolic Process
DNA Replication Initiation
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Nuclear Speck Organization
DNA Duplex Unwinding
DNA Geometric Change
Cell Cycle Process
DNA-dependent DNA Replication
Nucleosome Assembly
Nucleus Organization
Regulation Of Growth Rate
Protein Poly-ADP-ribosylation
Chromatin Assembly
Nucleosome Organization
Cell Cycle
Double-strand Break Repair
Chromatin Assembly Or Disassembly
G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecular Complex Assembly
Protein-DNA Complex Assembly
Transcription Initiation From RNA Polymerase II Promoter
Mitotic Cell Cycle Process
DNA Packaging
Cellular Metabolic Process
Mitotic Cell Cycle
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Transcription Regulatory Region DNA Binding
DNA-templated Transcription, Initiation
Protein Autoprocessing
DNA Unwinding Involved In DNA Replication
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Methylation On Cytosine
DNA Replication
Positive Regulation Of SMAD Protein Import Into Nucleus
Chromatin Silencing At RDNA
Regulation Of SMAD Protein Import Into Nucleus
Gene Expression
Macrophage Differentiation
RNA Splicing
Positive Regulation Of Viral Genome Replication
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
altering
breaks
checkpoint
chemo
conjunction
cooperate
disassembly
dsb
dsbs
dynamic
facilitates
fact
gammah2ax
h2ax
h2b
h2bub1
h3k56ac
homolog
mechanistic
monoubiquitination
phenocopied
proper
pursuing
rational
repair
rnf40
strand
timely
ty
Tagcloud (Difference)
?
altering
breaks
checkpoint
chemo
conjunction
cooperate
disassembly
dsb
dsbs
dynamic
facilitates
fact
gammah2ax
h2ax
h2b
h2bub1
h3k56ac
homolog
mechanistic
monoubiquitination
phenocopied
proper
pursuing
rational
repair
rnf40
strand
timely
ty
Tagcloud (Intersection)
?