SUPT16H and H3F3A

Number of citations of the paper that reports this interaction (PMID 15616580)
80

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SUPT16H	H3F3A
Gene Name		suppressor of Ty 16 homolog (S. cerevisiae)	H3 histone, family 3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: GTF2E2 H2AFX H3F3A HIST1H2AI MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2	25 interactors: ASF1A ASF1B BPTF BRD1 CABIN1 CARM1 CBX3 CHD1 CREBBP DAXX KAT2B KMT2A MAPK9 NOS3 PARP10 SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H TLE2 UHRF1 ZMYND11
Entrez ID		11198	3020
HPRD ID		16088	03082
Ensembl ID		ENSG00000092201	ENSG00000163041
Uniprot IDs		Q9Y5B9	B2R4P9 P84243
PDB IDs			2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Heterocycle Metabolic Process DNA Replication Initiation Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nuclear Speck Organization DNA Duplex Unwinding DNA Geometric Change Cell Cycle Process DNA-dependent DNA Replication Nucleosome Assembly Nucleus Organization Regulation Of Growth Rate Protein Poly-ADP-ribosylation Chromatin Assembly Nucleosome Organization Cell Cycle Double-strand Break Repair Chromatin Assembly Or Disassembly G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecular Complex Assembly Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Process DNA Packaging Cellular Metabolic Process Mitotic Cell Cycle DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription Regulatory Region DNA Binding DNA-templated Transcription, Initiation Protein Autoprocessing DNA Unwinding Involved In DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Methylation On Cytosine DNA Replication Positive Regulation Of SMAD Protein Import Into Nucleus Chromatin Silencing At RDNA Regulation Of SMAD Protein Import Into Nucleus Gene Expression Macrophage Differentiation RNA Splicing Positive Regulation Of Viral Genome Replication	Chromatin Organization Chromatin Modification Chromosome Organization Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Remodeling Gene Expression Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA Replication-independent Nucleosome Assembly Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Nucleosome Assembly Internal Protein Amino Acid Acetylation Peptidyl-lysine Modification Protein Acetylation Chromatin Assembly Negative Regulation Of Cellular Metabolic Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Viral Process
Tagcloud ?		altering breaks checkpoint chemo conjunction cooperate disassembly dsb dsbs dynamic facilitates fact gammah2ax h2ax h2b h2bub1 h3k56ac homolog mechanistic monoubiquitination phenocopied proper pursuing rational repair rnf40 strand timely ty	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Difference) ?		altering breaks checkpoint chemo conjunction cooperate disassembly dsb dsbs dynamic facilitates fact gammah2ax h2ax h2b h2bub1 h3k56ac homolog mechanistic monoubiquitination phenocopied proper pursuing rational repair rnf40 strand timely ty	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Intersection) ?