SUPT16H and H2AC13

Number of citations of the paper that reports this interaction (PubMedID 18206970)
64

Data Source:
HPRD (in vitro)

		SUPT16H	H2AC13
Description		SPT16 homolog, facilitates chromatin remodeling subunit	H2A clustered histone 13
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex FACT Complex	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of DNA-templated Transcription, Elongation	Heterochromatin Formation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		15 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A H3C1 H4C1 MCM3 MCM4 NEK9 PARP1 RNF10 SREK1 SRPK2 SUMO2 USP7	2 interacting genes: RNF168 SUPT16H
Entrez ID		11198	8329
HPRD ID		16088	04153
Ensembl ID		ENSG00000092201	ENSG00000196747
Uniprot IDs		Q9Y5B9	A4FTV9 P0C0S8
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL 8I17 8YJF 8YJM 9EH2	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7BG9 7E8D 7JO9 7JOA 7TAN 7U50 7U51 7U52 7U53 7UV9 8ATF 8AV6 8GUI 8GUJ 8GUK 8OFF 8QZM 8VOB 8VWS 8VWT 8VWU 8VWV 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM
Enriched GO Terms of Interacting Partners?		Chromosome Chromosome, Telomeric Region Chromatin Remodeling Structural Constituent Of Chromatin Chromatin Organization Telomere Organization Nucleus Nucleosome Mitotic DNA Replication Initiation Regulation Of Establishment Of Protein Localization To Telomere Nucleoplasm Regulation Of Establishment Of Protein Localization To Chromosome RNA Binding DNA Binding CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Epigenetic Regulation Of Gene Expression Regulation Of Telomere Maintenance Nucleosome Assembly Single-stranded DNA Helicase Activity DNA Strand Elongation Nucleic Acid Metabolic Process Chromosome Organization Protein Heterodimerization Activity Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication Initiation Regulation Of Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Gene Expression, Epigenetic Protein-DNA Complex Assembly NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Macromolecule Metabolic Process NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein Localization To Chromatin DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process DNA Recombination	Nucleosome Binding Regulation Of DNA-templated Transcription Elongation Histone H2AK15 Ubiquitin Ligase Activity Histone Ubiquitin Ligase Activity FACT Complex Chromatin Remodeling DNA Metabolic Process Nucleosome Disassembly Protein-DNA Complex Disassembly DNA Repair Chromatin Organization DNA Damage Response Transcription Elongation Factor Complex Isotype Switching Double-strand Break Repair Via Classical Nonhomologous End Joining Catalytic Complex DNA Repair-dependent Chromatin Remodeling Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response K63-linked Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments Transcription Elongation By RNA Polymerase II Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Interstrand Cross-link Repair DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of DNA-templated Transcription, Elongation B Cell Activation Involved In Immune Response Cellular Response To Stress Protein K63-linked Ubiquitination
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