RAC2 and ARHGDIB

Number of citations of the paper that reports this interaction (PubMedID 10655614)
0

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		RAC2	ARHGDIB
Description		Rac family small GTPase 2	Rho GDP dissociation inhibitor beta
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding	GTPase Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Cellular Response To Redox State Negative Regulation Of Trophoblast Cell Migration
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		21 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4	14 interacting genes: ANKRD1 APP CASP3 CDC42 CEBPA EZR RAC1 RAC2 RAC3 RHOA RHOH UBE3A UFM1 VAV1
Entrez ID		5880	397
HPRD ID		03628	04162
Ensembl ID		ENSG00000128340	ENSG00000111348
Uniprot IDs		P15153 V9H0H7	P52566
PDB IDs		1DS6 2W2T 2W2V 2W2X	1DS6 5H1D
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity	Intracellular Signal Transduction Intracellular Signaling Cassette Actin Filament Organization Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Establishment Or Maintenance Of Cell Polarity Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Immune System Process Cortical Cytoskeleton Organization Regulation Of Cell Adhesion GTPase Activity Chemotaxis Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion GTP Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction G Protein Activity Regulation Of Actin Filament-based Process Establishment Of Epithelial Cell Apical/basal Polarity NADPH Oxidase Complex Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Respiratory Burst Cerebral Cortex GABAergic Interneuron Development Cellular Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Leukocyte Migration Postsynapse Endocytosis Polarized Epithelial Cell Differentiation Protein Kinase Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Periphery Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Developmental Process Positive Regulation Of Cell Adhesion Establishment Of Epithelial Cell Polarity Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Vesicle-mediated Transport Response To Cytokine Positive Regulation Of Lamellipodium Organization Regulation Of Synapse Organization
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