RAC2 and ICMT

Number of citations of the paper that reports this interaction (PubMedID 9614111)
0

Data Source:
HPRD (in vitro)

		RAC2	ICMT
Description		Rac family small GTPase 2	isoprenylcysteine carboxyl methyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity
	Biological Process	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	C-terminal Protein Methylation Protein Targeting To Membrane Nuclear Envelope Organization Methylation Protein Modification Process S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Protein Maturation
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation RAS processing
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)
Interacting Genes		21 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4	12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32
Entrez ID		5880	23463
HPRD ID		03628	09321
Ensembl ID		ENSG00000128340	ENSG00000116237
Uniprot IDs		P15153 V9H0H7	B3KS61 O60725 Q7Z750
PDB IDs		1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity	Telencephalon Cell Migration Forebrain Cell Migration GTPase Activity GTP Binding Erythrocyte Enucleation Positive Regulation Of Cellular Component Biogenesis G Protein Activity Regulation Of Cell Projection Assembly Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Positive Regulation Of Locomotion Positive Regulation Of Ruffle Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Chemotaxis Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Locomotion Regulation Of Respiratory Burst Actin Cytoskeleton Organization Cell Projection Assembly Respiratory Burst Regulation Of Actin Filament-based Process Regulation Of Reactive Oxygen Species Metabolic Process Superoxide Anion Generation Response To External Biotic Stimulus Positive Regulation Of Neutrophil Chemotaxis Myosin Binding Actin Filament-based Process Positive Regulation Of Leukocyte Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Lamellipodium Assembly Establishment Or Maintenance Of Cell Polarity Cerebral Cortex Cell Migration Regulation Of Ruffle Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Wnt Signaling Pathway, Planar Cell Polarity Pathway Tissue Homeostasis Anatomical Structure Homeostasis Positive Regulation Of Lamellipodium Organization Cell Morphogenesis Lamellipodium Regulation Of Neuron Differentiation Membrane
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