RAC2 and DOCK2

Number of citations of the paper that reports this interaction (PubMedID 10559471)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RAC2	DOCK2
Description		Rac family small GTPase 2	dedicator of cytokinesis 2
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding T Cell Receptor Binding
	Biological Process	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Myoblast Fusion Cell Migration Actin Cytoskeleton Organization T Cell Proliferation T Cell Activation Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Activation Alpha-beta T Cell Proliferation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	Nef and signal transduction Neutrophil degranulation RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Acne (severe) ( 24927181) Bipolar disorder ( 34002096) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Coronary artery aneurysm in Kawasaki disease ( 33772158) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		21 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4	49 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CEBPA CRKL CYSRT1 ELMO1 GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1
Entrez ID		5880	1794
HPRD ID		03628	09121
Ensembl ID		ENSG00000128340	ENSG00000134516
Uniprot IDs		P15153 V9H0H7	H0YB76 Q5XG91 Q92608
PDB IDs		1DS6 2W2T 2W2V 2W2X	2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity	Intermediate Filament Keratin Filament Identical Protein Binding Cytosol Structural Constituent Of Skin Epidermis SH3 Domain Binding Erythrocyte Enucleation Structural Molecule Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of MRNA Splicing, Via Spliceosome
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