RAC2 and ADAM22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAC2	ADAM22
Description		Rac family small GTPase 2	ADAM metallopeptidase domain 22
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome	Plasma Membrane Membrane Axon Cell Projection Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Signaling Receptor Activity
	Biological Process	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Positive Regulation Of Synaptic Transmission
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	LGI-ADAM interactions
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)
Interacting Genes		21 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4	9 interacting genes: APP DYRK1A DYRK3 EPS8 LCOR LGI1 RAC2 YWHAB YWHAZ
Entrez ID		5880	53616
HPRD ID		03628	04751
Ensembl ID		ENSG00000128340	ENSG00000008277
Uniprot IDs		P15153 V9H0H7	H7C3I4 Q08AL8 Q9P0K1
PDB IDs		1DS6 2W2T 2W2V 2W2X	3G5C 5Y2Z 5Y31 7CQF 8HPY 8HQ1 8HQ2 8Y6B
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity	Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Nucleus Protein Serine/threonine/tyrosine Kinase Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Neuron Recognition Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Histone H3T45 Kinase Activity Protein Sequestering Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Intracellular Signaling Cassette Protein Phosphorylation Adult Locomotory Behavior Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization Phosphorylation Actin Filament Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Synaptic Target Recognition PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cell Recognition Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Axon Midline Choice Point Recognition Positive Regulation Of Chemotaxis Dendrite Endosome To Plasma Membrane Transport Vesicle
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