DNAJB4 and TBL1X

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DNAJB4	TBL1X
Name		DnaJ heat shock protein family (Hsp40) member B4	transducin beta like 1 X-linked
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Z Disc	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	ATPase Activator Activity Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Histone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Response To Heat	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		None	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events Cytoprotection by HMOX1 Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body mass index ( 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cutaneous melanoma or hair colour ( 32341527 ) Diastolic blood pressure ( 30224653 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Waist circumference ( 25673412 )	Prostate cancer ( 23535732 ) Refractive error ( 32231278 )
Novel Interactors		None recorded	1 novel interactors: IQCB1
Interacting Genes		11 interacting genes: HSPA1A HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2	31 interacting genes: ARL2 ARL3 CDC34 CORO2A CTNNB1 DDB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I
Entrez ID		11080	6907
HPRD ID		07486	02183
Ensembl ID		ENSG00000162616	ENSG00000101849
Uniprot IDs		B4DNN2 Q9UDY4	O60907
PDB IDs		Not available	2XTC 2XTD 2XTE
GO Terms Enriched among Interactors		Regulation Of Protein Stability Protein Folding Cellular Heat Acclimation Protein Stabilization Unfolded Protein Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Enzyme Binding Disordered Domain Specific Binding Protein Refolding Transcription Corepressor Activity ATP-dependent Protein Folding Chaperone COP9 Signalosome Regulation Of Cellular Response To Stress Cellular Response To Alkaloid Cellular Response To Heat Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Folding Chaperone Heat Shock Protein Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lung Blood Pressure Positive Regulation Of Nucleocytoplasmic Transport Nuclear Mineralocorticoid Receptor Binding Regulation Of Nitric Oxide Metabolic Process Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Polynucleotide Adenylyltransferase Activity Ubiquitin Protein Ligase Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Denatured Protein Binding Negative Regulation Of RNA Metabolic Process Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Positive Regulation Of Transforming Growth Factor Beta3 Production Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Response To Alkaloid Cellular Response To UV Nuclear DNA-directed RNA Polymerase Complex Ribonucleoprotein Complex	Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Repressor Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Transcription Corepressor Activity Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Structural Constituent Of Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Nucleosome Regulation Of Primary Metabolic Process Female Courtship Behavior Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Maintenance Of Protein Location In Nucleus Chromatin Lung Epithelial Cell Differentiation Lung Cell Differentiation Chromosome, Telomeric Region Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Chromatin Binding Chromosome Regulation Of RNA Metabolic Process Thyroid Hormone Binding Negative Regulation Of JNK Cascade Shelterin Complex Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleosome Assembly Nuclear Body Negative Regulation Of Intracellular Signal Transduction Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Localization In Organelle Modification-dependent Protein Catabolic Process