DNAJB4 and POLR1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DNAJB4	POLR1D
Description		DnaJ heat shock protein family (Hsp40) member B4	RNA polymerase I and III subunit D
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Z Disc	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol Nuclear DNA-directed RNA Polymerase Complex
	Molecular Function	ATPase Activator Activity Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Response To Heat	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase III
Pathways			Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)	Body mass index ( 26426971)
Interacting Genes		11 interacting genes: HSPA1A HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2	15 interacting genes: CDC25A CEBPA CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN
Entrez ID		11080	51082
HPRD ID		07486	17877
Ensembl ID		ENSG00000162616	ENSG00000186184
Uniprot IDs		B4DNN2 Q9UDY4	A0A087WTY1 P0DPB5 P0DPB6
PDB IDs			7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Stability Protein Folding Cellular Heat Acclimation Protein Stabilization Unfolded Protein Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Enzyme Binding Disordered Domain Specific Binding Protein Refolding Transcription Corepressor Activity ATP-dependent Protein Folding Chaperone COP9 Signalosome Regulation Of Cellular Response To Stress Cellular Response To Alkaloid Cellular Response To Heat Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Folding Chaperone Heat Shock Protein Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lung Blood Pressure Positive Regulation Of Nucleocytoplasmic Transport Nuclear Mineralocorticoid Receptor Binding Regulation Of Nitric Oxide Metabolic Process Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Polynucleotide Adenylyltransferase Activity Ubiquitin Protein Ligase Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Denatured Protein Binding Negative Regulation Of RNA Metabolic Process Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Positive Regulation Of Transforming Growth Factor Beta3 Production Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Response To Alkaloid Cellular Response To UV Nuclear DNA-directed RNA Polymerase Complex Ribonucleoprotein Complex	CHOP-C/EBP Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Protein Domain Specific Binding Regulation Of RNA Biosynthetic Process Protein-folding Chaperone Binding Transcription By RNA Polymerase I Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression ATPase Activator Activity Nucleoplasm Cytoplasm Regulation Of Primary Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cortex Integrated Stress Response Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Dexamethasone Macrophage Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Xenobiotic Stimulus Gland Development Negative Regulation Of Biosynthetic Process Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis
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