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HSF2BP and CDC73
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
HSF2BP
CDC73
Gene Name
heat shock transcription factor 2 binding protein
cell division cycle 73
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Nucleus
Nucleoplasm
Cdc73/Paf1 Complex
Molecular Function
RNA Polymerase II Core Binding
Protein Binding
Biological Process
Transcription From RNA Polymerase II Promoter
Spermatogenesis
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Endodermal Cell Fate Commitment
Transcription, DNA-templated
MRNA Polyadenylation
Cell Cycle
Negative Regulation Of Cell Proliferation
Histone Monoubiquitination
Wnt Signaling Pathway
Stem Cell Maintenance
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of MRNA 3'-end Processing
Protein Destabilization
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2B Ubiquitination
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Fibroblast Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Cellular Response To Lipopolysaccharide
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
Hedgehog 'on' state
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Hedgehog
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Subcutaneous adipose tissue (
22589738
)
Protein-Protein Interactions
4 interactors:
CDC73
HSF2
UBE2I
UPF2
30 interactors:
ALAS1
ANXA6
CCDC155
CEP70
CTNNB1
DDAH2
FAF1
FSD2
GC
GOLGA2
HAP1
HIST1H1C
HSF2BP
HSPA4
ITFG1
KCNH2
KIAA1549
KIDINS220
MCM3AP
MTUS2
PITHD1
RNF20
RNF40
TCEA1
TCF4
TFCP2
TOMM20
TSGA10
VPS37B
WWC1
Entrez ID
11077
79577
HPRD ID
05186
09581
Ensembl ID
ENSG00000160207
ENSG00000134371
Uniprot IDs
O75031
Q6IAT7
Q6P1J9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of SUMO Transferase Activity
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Histone H2B Ubiquitination
Cellular Localization
Positive Regulation Of Glycoprotein Biosynthetic Process
Establishment Of Localization In Cell
Genitalia Morphogenesis
Positive Regulation Of Glycoprotein Metabolic Process
Organelle Organization
Histone Monoubiquitination
Regulation Of Glycoprotein Biosynthetic Process
Establishment Of Protein Localization To Organelle
Protein Localization
Chromosome Organization
Histone Ubiquitination
Protein Import
Positive Regulation Of Epithelial To Mesenchymal Transition
Cellular Process
Cytoplasmic Transport
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Histone Methylation
Intracellular Transport
Positive Regulation Of Neurogenesis
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Organ Growth
Organelle Localization
Transcription-coupled Nucleotide-excision Repair
Regulation Of Oligodendrocyte Differentiation
Protein Targeting
Protein Monoubiquitination
Myoblast Differentiation
Regulation Of Intracellular Transport
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
Chromosome Localization To Nuclear Envelope Involved In Synapsis
Negative Regulation Of Potassium Ion Export
Regulation Of Myelination
Positive Regulation Of Intracellular Signal Transduction
Skin Morphogenesis
Vesicle Localization
Regulation Of Histone Methylation
Positive Regulation Of Stem Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Development
Genitalia Development
Regulation Of Intracellular Signal Transduction
Skin Development
Regulation Of Epithelial To Mesenchymal Transition
Protein Localization To Organelle
Protein Transmembrane Transport
Tagcloud
?
1379delt
affecting
caucasian
encoded
fibroma
hpt
hyperparathyroidism
hystologically
instrumental
jaw
jt
l460lfs
mandible
modelling
moiety
mtt
ossifying
parafibromin
parathyroid
partners
proband
pth
relatives
sanger
sca
silico
terminus
underlie
vast
Tagcloud (Difference)
?
1379delt
affecting
caucasian
encoded
fibroma
hpt
hyperparathyroidism
hystologically
instrumental
jaw
jt
l460lfs
mandible
modelling
moiety
mtt
ossifying
parafibromin
parathyroid
partners
proband
pth
relatives
sanger
sca
silico
terminus
underlie
vast
Tagcloud (Intersection)
?