HSF2BP and HEY2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSF2BP	HEY2
Description		heat shock transcription factor 2 binding protein	hes related family bHLH transcription factor with YRPW motif 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription By RNA Polymerase II Male Meiosis I Female Meiosis I Spermatogenesis Double-strand Break Repair Involved In Meiotic Recombination	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Hypertrophy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Pattern Specification Process Heart Development Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation By RNA Polymerase II Labyrinthine Layer Blood Vessel Development Blood Vessel Endothelial Cell Differentiation Artery Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophilic esophagitis ( 25017104) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroid peroxidase levels ( 29678681) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Systolic blood pressure ( 30578418)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 35210625 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)
Interacting Genes		293 interacting genes: ABI2 ABLIM1 ACTN3 ADD1 ANAPC16 ANKRD55 ANKS1B ARHGAP45 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ATOSB ATXN7L2 BARD1 BAX BAZ2B BCAS2 BEND7 BEX2 BLK BMI1 BYSL C10orf88 C18orf54 C1orf35 C1orf94 C4orf46 CAMSAP3 CARD9 CASS4 CATSPERT CBX8 CBY2 CCDC116 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC198 CCDC33 CCHCR1 CCSER1 CDC37 CDC73 CDCA7L CDR2L CDYL2 CEP55 CEP57 CFAP263 CFAP90 CIMAP1B CIMAP1D CKS1B CLIP4 CNNM1 CNNM3 CNOT2 COIL CTSZ CTTNBP2 CTTNBP2NL CWF19L2 DALRD3 DCDC2B DEFB112 DMAP1 DMRT3 DOCK8 DPF2 DRC4 DUSP13B EAF1 EIF3D ELOA2 EMD ENKD1 EPHB3 EPM2AIP1 FAM107A FAM110A FAM110B FAM124B FAM161B FAM228A FAM90A1 FBXL9P FBXO44 FHL2 FHL3 FLYWCH1 FUT9 GAS2L2 GCM2 GEM GGN GNL3L GOLGA1 GPANK1 GPATCH2L GPBP1 GPKOW GPSM3 H2AC25 HASPIN HCK HDAC4 HEXIM2 HEY2 HNRNPH2 HOMEZ HOXB5 HOXC8 HSF2 IER2 IL16 INO80B INPP5J INSYN2A IPMK IQCC ITGB3BP JRK KANK2 KAT5 KIAA0408 KIF24 KIF5B KIF9 KIFC3 KLF4 L3MBTL2 L3MBTL3 L3MBTL4 LAGE3 LEP LGALS4 LMO4 LNX1 LRRC56 LRRN4 LUZP4 MAGED1 MAGOHB MARCHF7 MECOM MEF2A MFAP1 MISP MKRN3 MVB12A MYOZ3 NAB2 NCK2 NFIL3 NHSL2 NME4 NPPA NSMF NTAQ1 NUDT10 NXF1 OPTN P2RX7 PAK6 PAPSS2 PARD6B PDLIM7 PICK1 PKD2 PKN1 PKP1 PLB1 PLEKHA2 PLEKHA7 PNMA5 POGZ POLDIP3 POMC PPM1K PPP1R18 PRPF18 PRPF3 PRPF31 PRR5L PSMA1 PSTPIP1 RAB11FIP2 RAB36 RAB3IL1 RAD51D RALY RBM17 RBM41 RBM48 RCOR3 REXO4 RIBC1 RIN1 RNF135 RNF169 ROBO3 RPS28 RTP5 SAMD4A SAPCD1 SART1 SAXO1 SAXO4 SCNM1 SDCBP SELENOV SEMA3B SEMA4C SEPTIN1 SEPTIN9 SH2D4A SHFL SHISA6 SIRPA SLAIN1 SLC6A1 SMARCB1 SMARCD1 SMG9 SNAPC1 SNW1 SNX18 SNX21 SPATA22 SPEG SPG7 SPMIP4 SPMIP6 SPRED1 SPRY1 SYCE1L SYNGAP1 TAB2 TAGAP TASOR2 TBC1D1 TBC1D30 TCEA2 TCF19 TEPSIN TFIP11 THAP6 TMEFF2 TMSB4X TNS4 TOX2 TP53BP2 TRAF5 TRARG1 TSEN15 TSGA10IP TSHZ3 TTC23 TTC9C TULP3 UBE2I UPF2 UPRT USP20 VEZF1 VHL VPS72 WASF1 WASHC1 WDR25 YJU2B ZBTB16 ZBTB42 ZC2HC1C ZCWPW2 ZFC3H1 ZGPAT ZNF185 ZNF250 ZNF417 ZNF511 ZNF564 ZNF581 ZNF587 ZNF648 ZNF688 ZNF774 ZNF835 ZNF84 ZNF844	27 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4
Entrez ID		11077	23493
HPRD ID		05186	05243
Ensembl ID		ENSG00000160207	ENSG00000135547
Uniprot IDs		O75031 Q6IAT7	Q5TF93 Q9UBP5
PDB IDs		7BDX 7LDG 8A50 8A51
Enriched GO Terms of Interacting Partners?		Protein Binding Cytoskeleton MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Zonula Adherens Maintenance Nucleus Centrosome Cytoskeletal Anchor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cell Projection Nucleoplasm Nuclear Speck RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Motile Cilium Adherens Junction Maintenance Ciliary Basal Body Microtubule-based Process Regulation Of RNA Metabolic Process MRNA Processing Zonula Adherens Negative Regulation Of RNA Metabolic Process	Intermediate Filament RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis HLH Domain Binding Cardiac Right Ventricle Formation Keratin Filament Chromatin Regulation Of Transcription By RNA Polymerase II Cytosol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Identical Protein Binding Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Heart Left/right Asymmetry Transcription Corepressor Binding Cardiac Ventricle Formation Negative Regulation Of Transcription By RNA Polymerase II Cartilage Morphogenesis E-box Binding Regulation Of Cardioblast Proliferation Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Artery Morphogenesis Cardiac Chamber Formation Protein Dimerization Activity Regulation Of Cellular Response To Growth Factor Stimulus DNA Binding Protein Deacetylation Protein Lysine Deacetylase Activity Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process
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