TRIM31 and UBE2D4

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		TRIM31	UBE2D4
Gene Name		tripartite motif containing 31	ubiquitin-conjugating enzyme E2D 4 (putative)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol
	Molecular Function	Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell	Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Beta-2 microglubulin plasma levels ( 23417110)
Protein-Protein Interactions		17 interactors: IKBKG MAGEA1 MAGEA2B MKRN3 MNAT1 TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2W USP7 ZSCAN1	90 interactors: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 LRSAM1 MAGEA11 MAP3K1 MARCH3 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF26 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBE4A UBOX5 UBTD1 UFM1 UHRF2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		11074	51619
HPRD ID		10281	14242
Ensembl ID		ENSG00000204616	ENSG00000078967
Uniprot IDs		Q2L6J1 Q9BZY9	Q9Y2X8
PDB IDs		2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Cellular Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Protein Modification Process Toll-like Receptor Signaling Pathway Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Response To Stress Protein Metabolic Process Cellular Metabolic Process Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Immune Response-regulating Signaling Pathway Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Cellular Response To Oxygen Levels	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Viral Entry Into Host Cell Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Metabolic Process Negative Regulation Of Viral Process Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Viral Transcription Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Regulation Of Signal Transduction Innate Immune Response Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Interferon-gamma Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Interferon-gamma Programmed Cell Death Cell Death Death Histone Monoubiquitination
Tagcloud ?		advanced aims biological bronchial colony corresponding cyclin downregulation h1299 h157 hbe immumohistochemistry lines lung metastasis might nodal nsclc overexpression pattern plasmid regulator roles serve small suppressor tissues tnm transfection	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Difference) ?		advanced aims biological bronchial colony corresponding cyclin h1299 h157 hbe immumohistochemistry lines lung metastasis might nodal nsclc overexpression pattern plasmid regulator roles serve small suppressor tissues tnm transfection	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Intersection) ?		downregulation