NDFIP2 and UQCRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NDFIP2	UQCRH
Description		Nedd4 family interacting protein 2	ubiquinol-cytochrome c reductase hinge protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endosome Endoplasmic Reticulum Golgi Apparatus Endosome Membrane Membrane Multivesicular Body Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Protein Binding WW Domain Binding	Protein Binding Quinol-cytochrome-c Reductase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Protein Transport	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration Proton Transmembrane Transport
Pathways			Respiratory electron transport Complex III assembly Complex III assembly
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Bullous pemphigoid ( 34011352) Leisure-time exercise behaviour (age-stratified) ( 30102679) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Pancreatic cancer ( 20686608) Smoking status (ever vs never smokers) ( 30643258) Youthful appearance (self-reported) ( 32339537)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: AQP2 ITCH LYN NEDD4 NEDD4L SMURF1 UQCRH WWP2 YAP1	7 interacting genes: ARL8A ENTREP3 NDFIP1 NDFIP2 NPM1 PRRG1 RNF24
Entrez ID		54602	7388
HPRD ID		17629	15629
Ensembl ID		ENSG00000102471	ENSG00000173660
Uniprot IDs		B4DGY6 Q9NV92	P07919 Q567R0
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Transport Protein Polyubiquitination Transmembrane Transporter Binding Ubiquitin Protein Ligase Activity Receptor Metabolic Process Regulation Of Cell Projection Organization C-X-C Chemokine Receptor CXCR4 Signaling Pathway Protein Monoubiquitination Bud Elongation Involved In Lung Branching Regulation Of Nervous System Development Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Protein K63-linked Ubiquitination Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Synapse Organization Regulation Of Monoatomic Cation Transmembrane Transport Branch Elongation Of An Epithelium Negative Regulation Of Signal Transduction Negative Regulation Of Sodium Ion Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Negative Regulation Of Cell Communication Tolerance Induction Proline-rich Region Binding Protein Ubiquitination Axis Elongation Negative Regulation Of Transmembrane Transport Innervation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Dendrite Extension Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metal Ion Transport Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Neurogenesis Positive Regulation Of Macromolecule Metabolic Process	WW Domain Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Post-translational Protein Modification Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Positive Regulation Of Protein Modification Process Intracellular Transport Regulation Of Endoribonuclease Activity Negative Regulation Of Protein Transport Negative Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Cellular Localization Regulation Of Protein Modification Process Positive Regulation Of Centrosome Duplication Establishment Of Localization In Cell Membrane Golgi Membrane Negative Regulation Of Establishment Of Protein Localization Vacuolar Transport Negative Regulation Of Isotype Switching Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Endosome Negative Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Tat Protein Binding Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization Ribosomal Subunit Export From Nucleus Negative Regulation Of Centrosome Duplication Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Immunoglobulin Production Spindle Pole Centrosome Ribosomal Large Subunit Binding Endosome Membrane Alpha-beta T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Type 2 Immune Response
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