DIDO1 and KCNK4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DIDO1	KCNK4
Name		death inducer-obliterator 1	potassium two pore domain channel subfamily K member 4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Cytoskeleton	Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex Potassium Channel Complex Cell Projection
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Temperature-gated Cation Channel Activity Mechanosensitive Potassium Channel Activity
	Biological Process	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Apoptotic Signaling Pathway	Monoatomic Ion Transport Potassium Ion Transport Memory Response To Mechanical Stimulus Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Acidic PH Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport Cellular Response To Arachidonate Response To Ultrasound
Pathways		None	TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
GWAS		Mean corpuscular volume ( 32888494 ) Menopause (age at onset) ( 26414677 )	Crohn's disease ( 28067908 ) Sarcoidosis ( 22837380 ) Vitiligo ( 27723757 )
Novel Interactors		None recorded	1 novel interactors: NRG1
Interacting Genes		15 interacting genes: APP ARAF CEBPA DVL3 H3C1 HNRNPK KCNK4 LRRK2 SRPK2 SRSF1 SUMO2 VHL WEE2-AS1 WWP1 WWP2	3 interacting genes: DIDO1 ORMDL1 RPL14
Entrez ID		11083	50801
HPRD ID		10363	12037
Ensembl ID		ENSG00000101191	ENSG00000182450
Uniprot IDs		Q9BTC0	Q2YDA1 Q9NYG8
PDB IDs		2M3H 4L7X	3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Proteolysis Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process MRNA 5'-splice Site Recognition Positive Regulation Of Proteolysis Cellular Response To Manganese Ion Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Golgi-associated Vesicle Negative Regulation Of RNA Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Catecholamine Negative Regulation Of Nucleobase-containing Compound Metabolic Process Memory Protein Serine/threonine Kinase Binding MAP Kinase Kinase Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Modification Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Presynaptic Cytosol Amyloid Fibril Formation Positive Regulation Of Macrophage Activation MRNA Splice Site Recognition Positive Regulation Of Inflammatory Response Positive Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Frizzled Binding Cellular Response To Metal Ion Positive Regulation Of Transcription By RNA Polymerase II	Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cardiac Muscle Cell Myoblast Differentiation Sphingomyelin Biosynthetic Process Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Large Ribosomal Subunit Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Heart Trabecula Morphogenesis