CLCN5 and CFL1

Number of citations of the paper that reports this interaction (PMID 12904289)
11

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CLCN5	CFL1
Gene Name		chloride channel, voltage-sensitive 5	cofilin 1 (non-muscle)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Part Of Cell	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity ATP Binding Antiporter Activity	Actin Binding Protein Binding
	Biological Process	Transport Endocytosis Excretion Ion Transmembrane Transport Regulation Of Anion Transport Transmembrane Transport Chloride Transmembrane Transport	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis
Pathways		Ion channel transport Stimuli-sensing channels	Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		4 interactors: CFL1 MAGI1 WWP1 WWP2	37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		1184	1072
HPRD ID		02053	03261
Ensembl ID		ENSG00000171365	ENSG00000172757
Uniprot IDs		A8K4H5 B3KRR2 P51795	P23528
PDB IDs		2J9L 2JA3	1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Viral Entry Into Host Cell Entry Into Host Cell Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Viral Life Cycle Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Cell Size Neural Fold Formation Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Positive Regulation Of Protein Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Potassium Ion Transmembrane Transporter Activity Morphogenesis Of An Epithelial Fold Protein K63-linked Ubiquitination Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Transmembrane Transport Mitotic Cytokinesis Negative Regulation Of Transporter Activity Protein Autoubiquitination Cellular Macromolecule Catabolic Process Neural Crest Cell Migration Regulation Of Dendritic Spine Development Cellular Protein Modification Process Negative Regulation Of ERK1 And ERK2 Cascade	Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process
Tagcloud ?		3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy	anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?