CLCN5

Description		chloride voltage-gated channel 5
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding
	Biological Process	Renal System Process Monoatomic Ion Transport Chloride Transport Endocytosis Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels
Drugs
Diseases		Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: CXCR4
Interacting Genes		4 interacting genes: CFL1 MAGI1 WWP1 WWP2
Entrez ID		1184
HPRD ID		02053
Ensembl ID		ENSG00000171365
Uniprot IDs		A8K4H5 B3KRR2 P51795 V9GYG7
PDB IDs		2J9L 2JA3
Enriched GO Terms of Interacting Partners?		Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Cofilin-actin Rod Cell Leading Edge Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge C-X-C Motif Chemokine 12 Receptor Activity Anchoring Junction Ubiquitin Ligase Complex Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Protein Localization To Cell Leading Edge Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Cell Adhesion Extracellular Exosome Neural Fold Formation Actin Filament Fragmentation Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Cell-cell Junction Negative Regulation Of Lamellipodium Assembly CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Ubiquitin-protein Transferase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Cell Size Positive Regulation Of Synaptic Plasticity Potassium Channel Inhibitor Activity Positive Regulation Of Actin Filament Depolymerization Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Dendritic Spine Maintenance Actin Filament Severing Endothelial Cell Morphogenesis Ubiquitin Protein Ligase Activity Morphogenesis Of An Epithelial Fold Myelin Maintenance Alpha-actinin Binding Actin Binding Cellular Response To Interleukin-6 Response To Virus
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