IMMT and HTRA2

Number of citations of the paper that reports this interaction (PubMedID 31617661)
0

Data Source:
BioGRID (enzymatic study)

		IMMT	HTRA2
Description		inner membrane mitochondrial protein	HtrA serine peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	SAM Complex Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex
	Molecular Function	RNA Binding Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Inner Mitochondrial Membrane Organization Cristae Formation Mitochondrial Calcium Ion Homeostasis Neuron Cellular Homeostasis	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cristae formation	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Facial emotion recognition (sad faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		65 interacting genes: AKTIP ALB ANTKMT ARMCX3 ASCC2 ATXN1 BAG6 BMI1 C10orf88 C8orf33 CALM1 CCT5 CDC37 CFAP263 CHD3 CSTF2 DISC1 DSCR9 ECSIT EEF1A1 EP300 EXOSC10 FEZ1 FUBP1 HAP1 HIVEP1 HJURP HMOX2 HNRNPD HTRA2 KDM1A KIF22 KPNA2 LRIF1 MARCHF5 MRPL44 NDEL1 NDUFB9 NEK2 NIPSNAP3A NOS3 NRIP1 PDE4B PFDN1 PIAS4 PLA2G15 PPOX PRRC2A RER1 RNF10 RNF26 SDHAF2 SMN1 SNAPIN SRRT STMN4 STX5 TAF1D TK1 TNNT1 TRAF3IP1 TUBGCP3 TXNDC9 UBC UBQLN4	41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP
Entrez ID		10989	27429
HPRD ID		02658	05919
Ensembl ID		ENSG00000132305	ENSG00000115317
Uniprot IDs		B4DS66 C9J406 Q16891	A0A384MDW9 A0A8Q3SIX7 O43464
PDB IDs			1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K
Enriched GO Terms of Interacting Partners?		Centrosome Cytoplasm Cytosol Microtubule-based Process Protein Binding Protein-containing Complex Nucleoplasm Organelle Organization Retrograde Axonal Transport Axon Cytoplasm Axonal Transport Synaptic Vesicle Nucleus Organelle Localization Cytoskeleton Internal Peptidyl-lysine Acetylation Mitochondrion Microtubule Gamma-tubulin Binding Axo-dendritic Transport Organelle Transport Along Microtubule Negative Regulation Of Macroautophagy Radial Glia-guided Pyramidal Neuron Migration Protein Localization To Perinuclear Region Of Cytoplasm Nuclear Body Regulation Of Protein Metabolic Process RNA Binding Regulation Of Organelle Transport Along Microtubule Transport Along Microtubule Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Telomere Maintenance Via Telomerase Kinesin Complex Vesicle Transport Along Microtubule Regulation Of Metabolic Process Negative Regulation Of Autophagy Catabolic Process Gamma-tubulin Complex Regulation Of Telomere Maintenance Centrosome Separation Unfolded Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Cytoskeleton-dependent Intracellular Transport	Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process
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