NR4A2 and SMARCA2

Number of citations of the paper that reports this interaction (PMID 17043312)
26

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NR4A2	SMARCA2
Gene Name		nuclear receptor subfamily 4, group A, member 2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Coactivator Activity Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Adult Locomotory Behavior Post-embryonic Development Response To Inorganic Substance Gene Expression Death Response To Insecticide Central Nervous System Projection Neuron Axonogenesis Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription From RNA Polymerase II Promoter General Adaptation Syndrome Dopaminergic Neuron Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Aortic Smooth Muscle Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Response to statin therapy ( 20339536)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		15 interactors: BAZ1B CDKN1C CDKN2D COPS5 PIAS4 PPARG RARA RARB RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL	26 interactors: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA DPF3 ESR1 HIST1H3A KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 SDCBP SIN3B SS18
Entrez ID		4929	6595
HPRD ID		03493	02483
Ensembl ID		ENSG00000153234	ENSG00000080503
Uniprot IDs		F1D8N6 F5H4G9 P43354 Q53EL4 Q6NXU0	P51531 Q56A76 Q8N9Q1
PDB IDs		1OVL	2DAT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Retinoic Acid RNA Biosynthetic Process Heart Development Transcription From RNA Polymerase II Promoter Cardiovascular System Development Hormone-mediated Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Muscle Cell Differentiation Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Proliferation Intracellular Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Heart Morphogenesis DNA-templated Transcription, Initiation RNA Metabolic Process Muscle Structure Development Aortic Smooth Muscle Cell Differentiation Nitrogen Compound Metabolic Process Gene Expression	Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Chromatin Organization RNA Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Organelle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Intracellular Steroid Hormone Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Chromatin Remodeling Developmental Process Negative Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Steroid Hormone Mediated Signaling Pathway Anatomical Structure Development
Tagcloud ?		519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological indirectly invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		519d allograft artificial attenuate bac c19mc cxcl6 decidua evt evts extravillous feto foxl2 immunological indirectly invade microrna mirna mirnas myometrium naturally placenta placental trophoblast trophoblasts undifferentiated utr villous vts	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?