CBX5 and ARL5A

Number of citations of the paper that reports this interaction (PMID 12414990)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		CBX5	ARL5A
Gene Name		chromobox homolog 5	ADP-ribosylation factor-like 5A
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex	Intracellular
	Molecular Function	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding	GTP Binding
	Biological Process	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated	Small GTPase Mediated Signal Transduction
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1	6 interactors: APP CBX1 CBX3 CBX5 KPNA2 NMT1
Entrez ID		23468	26225
HPRD ID		05131	12343
Ensembl ID		ENSG00000094916
Uniprot IDs		P45973	Q9Y689
PDB IDs		3FDT 3I3C	1Z6Y 1ZJ6 2H16 2H17
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification See more	Viral Process Synaptic Growth At Neuromuscular Junction N-terminal Peptidyl-glycine N-myristoylation Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process N-terminal Protein Myristoylation Neuron Remodeling Protein Myristoylation Response To Light Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Response To Radiation NLS-bearing Protein Import Into Nucleus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle N-terminal Protein Amino Acid Modification Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Rhodopsin Mediated Signaling Pathway Regulation Of Body Fluid Levels Mating Behavior Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway See more
Tagcloud ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	alteration anterograde apparatus arf arl5b arls cargo classic dispersed endosome endosomes gfp golgi hela localised mannose perturbation q70l rab retrograde rnai shiga t30n tagged tgn tgn38 toxin trans transport
Tagcloud (Difference) ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	alteration anterograde apparatus arf arl5b arls cargo classic dispersed endosome endosomes gfp golgi hela localised mannose perturbation q70l rab retrograde rnai shiga t30n tagged tgn tgn38 toxin trans transport
Tagcloud (Intersection) ?