CBX5 and WHSC1L1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CBX5	WHSC1L1
Gene Name		chromobox homolog 5	Wolf-Hirschhorn syndrome candidate 1-like 1
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex	Nucleus Nucleoplasm Chromosome
	Molecular Function	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding	Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated	Chromatin Organization Transcription, DNA-templated Histone Methylation Negative Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K27 Methylation
Pathways		Factors involved in megakaryocyte development and platelet production	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)	Schizophrenia ( 22037555)
Protein-Protein Interactions		50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1	17 interactors: CBX3 CBX5 DAXX DOCK7 ETV3 GLYR1 H3F3C HIST1H1A HOXC4 MLLT6 MNDA SEPT6 SLU7 SPAG8 STAC3 UBE2I ZNF557
Entrez ID		23468	54904
HPRD ID		05131	06155
Ensembl ID		ENSG00000094916	ENSG00000147548
Uniprot IDs		P45973	B7ZL11 Q9BZ95
PDB IDs		3FDT 3I3C	2DAQ 4GND 4GNE 4GNF 4GNG
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Cell Division Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Neuroblast Polarity Cytokinesis Nucleosome Assembly MRNA 3'-splice Site Recognition Transcription, DNA-templated Chromatin Assembly RNA Metabolic Process RNA Biosynthetic Process Regulation Of Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Remodeling DNA Packaging Nucleobase-containing Compound Metabolic Process
Tagcloud ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	aside c5hch cys dimethylase fifth h3k36 h3k4 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified
Tagcloud (Difference) ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	aside c5hch cys dimethylase fifth h3k36 h3k4 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified
Tagcloud (Intersection) ?