CBX5 and DSN1

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vivo)

		CBX5	DSN1
Gene Name		chromobox homolog 5	DSN1, MIS12 kinetochore complex component
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex	MIS12/MIND Type Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division
Pathways		Factors involved in megakaryocyte development and platelet production	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1	11 interactors: AIMP2 APP CASC5 CBX3 CBX5 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT
Entrez ID		23468	79980
HPRD ID		05131	16455
Ensembl ID		ENSG00000094916	ENSG00000149636
Uniprot IDs		P45973	A8K3X3 Q9H410
PDB IDs		3FDT 3I3C
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification	Mitotic Nuclear Division Chromosome Segregation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Process Cell Cycle Chromosome Organization Organelle Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Centromere Complex Assembly Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Chromatin Modification Protein-DNA Complex Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Type II Pneumocyte Differentiation Chromatin Remodeling Intracellular Receptor Signaling Pathway Chromatin Organization
Tagcloud ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	altogether attachment cbf1 cenh3 cenp centromere centromeres centromeric cerevisiae connects cse4 ctf19 inner kinetochore lethality linker mark methylated microtubule mind mtw1 nnf1 nsl1 posttranslational principle r37 saccharomyces segregation termed
Tagcloud (Difference) ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis mitotic networks overview serves sight therapeutics tri	altogether attachment cbf1 cenh3 cenp centromere centromeres centromeric cerevisiae connects cse4 ctf19 inner kinetochore lethality linker mark microtubule mind mtw1 nnf1 nsl1 posttranslational principle r37 saccharomyces segregation termed
Tagcloud (Intersection) ?		methylated