CBX5 and DSN1

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vivo)

		CBX5	DSN1
Description		chromobox 5	DSN1 component of MIS12 kinetochore complex
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Fibrillar Center Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Cell Division
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Copper
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Factor VII activity ( 30642921) Hallux valgus ( 32131869)
Interacting Genes		61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT
Entrez ID		23468	79980
HPRD ID		05131	16455
Ensembl ID		ENSG00000094916	ENSG00000149636
Uniprot IDs		P45973 V9HWG0	A8K3X3 Q9H410
PDB IDs		3FDT 3I3C 8UXQ	5LSI 5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity	Outer Kinetochore Kinetochore Chromosome, Centromeric Region MIS12/MIND Type Complex Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Chromosome Segregation Nuclear Chromosome Segregation Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Chromosome Regulation Of Meiosis I Cell Division Kinetochore Assembly Kinetochore Organization Spindle Pole Pericentric Heterochromatin Regulation Of Meiotic Nuclear Division Cytosol Site Of DNA Damage Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Epigenetic Regulation Of Gene Expression Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Positive Regulation Of Neuron Apoptotic Process Organelle Assembly Regulation Of Chromosome Separation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Chromosome Localization Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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