CBX5 and NIPBL

Number of citations of the paper that reports this interaction (PubMedID 15882967)
0

Data Source:
BioGRID (unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		CBX5	NIPBL
Description		chromobox 5	NIPBL cohesin loading factor
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytosol Integrator Complex SMC Loading Complex Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex
	Molecular Function	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding Mediator Complex Binding Histone Deacetylase Binding Cohesin Loader Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Mitotic Sister Chromatid Segregation Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Mitotic Sister Chromatid Cohesion Brain Development Heart Development Sensory Perception Of Sound Intracellular Protein Localization Regulation Of Gene Expression Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Embryonic Organ Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Cranial Skeleton Morphogenesis Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gallbladder Development Uterus Morphogenesis Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins	Cohesin Loading onto Chromatin
Drugs		Copper
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Height ( 25282103 28552196 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D	11 interacting genes: CBX5 CDK6 DBN1 DSCR9 HINFP MAP1LC3C PCNA PCNT PRSS23 SP100 SUMO2
Entrez ID		23468	25836
HPRD ID		05131	10560
Ensembl ID		ENSG00000094916	ENSG00000164190
Uniprot IDs		P45973 V9HWG0	A0A590UJS4 Q6KC79
PDB IDs		3FDT 3I3C 8UXQ	6WG3 6WGE 7W1M
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity	DNA Damage Response Generation Of Neurons PML Body Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Postsynaptic Cytosol Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Maintenance Of Protein Location In Cell PCNA Complex Replisome Negative Regulation Of DNA-templated Transcription G1/S Transition Of Mitotic Cell Cycle Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Negative Regulation Of RNA Biosynthetic Process FBXO Family Protein Binding Cell Communication By Chemical Coupling Maintenance Of Protein Location Maintenance Of Location In Cell Maintenance Of Location PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Telomere Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neurogenesis Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of Fas Signaling Pathway
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