CBX5 and MIS12

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vitro, in vivo)

		CBX5	MIS12
Gene Name		chromobox homolog 5	MIS12 kinetochore complex component
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex	MIS12/MIND Type Complex Nucleus Cytosol
	Molecular Function	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division Kinetochore Assembly
Pathways		Factors involved in megakaryocyte development and platelet production	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1	10 interactors: CASC5 CBX3 CBX5 DSN1 HSP90AA1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		23468	79003
HPRD ID		05131	12379
Ensembl ID		ENSG00000094916	ENSG00000167842
Uniprot IDs		P45973	A8K1M4 Q9H081
PDB IDs		3FDT 3I3C
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification	Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Cell Cycle Cell Division Organelle Organization Attachment Of Spindle Microtubules To Kinetochore Chromosome Organization Microtubule Anchoring Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Maintenance Of Protein Location In Cell Protein Import Into Mitochondrial Outer Membrane Chromatin Modification Maintenance Of Protein Location Maintenance Of Location In Cell Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Chromatin Organization Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Histone H4-K5 Acetylation Histone H4-K8 Acetylation Chaperone-mediated Protein Complex Assembly Histone H4-K16 Acetylation Acrosome Assembly
Tagcloud ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?