PDE10A and TOP1

Number of citations of the paper that reports this interaction (PubMedID 12549820)
0

Data Source:
BioGRID (unspecified method)

		PDE10A	TOP1
Description		phosphodiesterase 10A	DNA topoisomerase I
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Synapse Glutamatergic Synapse	Nuclear Chromosome P-body Fibrillar Center Dense Fibrillar Component Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-DNA Complex Perikaryon
	Molecular Function	Nucleotide Binding Catalytic Activity Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding DNA Binding, Bending Isomerase Activity Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Supercoiled DNA Binding
	Biological Process	CAMP Catabolic Process Signal Transduction Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Response To Temperature Stimulus RRNA Transcription Response To Xenobiotic Stimulus Response To Gamma Radiation Programmed Cell Death Peptidyl-serine Phosphorylation Animal Organ Regeneration Circadian Regulation Of Gene Expression Embryonic Cleavage Rhythmic Process Response To CAMP Cellular Response To Luteinizing Hormone Stimulus
Pathways		cGMP effects G alpha (s) signalling events	SUMOylation of DNA replication proteins
Drugs		Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Mardepodect 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE PQ-10 Tofisopam Triflusal Trapidil	Irinotecan Dactinomycin Doxorubicin Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 27841878 28135244) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 32902719) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: CASP3 TOP1 WDR3	59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CEBPA CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PIAS4 PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TIAM1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5
Entrez ID		10846	7150
HPRD ID		17828	00535
Ensembl ID		ENSG00000112541	ENSG00000198900
Uniprot IDs		A0A1B1UZQ1 A0A1B1UZR0 Q9Y233	P11387 Q9BVT2
PDB IDs		2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5SDU 5SDV 5SDW 5SDX 5SDY 5SDZ 5SE0 5SE1 5SE2 5SE3 5SE4 5SE5 5SE6 5SE7 5SE8 5SE9 5SEA 5SEB 5SEC 5SED 5SEE 5SEF 5SEG 5SEH 5SEI 5SEJ 5SEK 5SEL 5SEM 5SEN 5SEO 5SEP 5SEQ 5SER 5SES 5SET 5SEU 5SEV 5SEW 5SEX 5SEY 5SEZ 5SF0 5SF1 5SF2 5SF3 5SF4 5SF5 5SF6 5SF7 5SF8 5SF9 5SFA 5SFB 5SFC 5SFD 5SFE 5SFF 5SFG 5SFH 5SFI 5SFJ 5SFK 5SFL 5SFM 5SFN 5SFO 5SFP 5SFQ 5SFR 5SFS 5SFT 5SFU 5SFV 5SFW 5SFX 5SFY 5SFZ 5SG0 5SG1 5SG2 5SG3 5SG4 5SG5 5SG6 5SG7 5SG8 5SG9 5SGB 5SGC 5SGD 5SGE 5SGF 5SGG 5SGH 5SGI 5SGJ 5SGK 5SGL 5SGM 5SGN 5SGO 5SGP 5SGQ 5SGR 5SGS 5SGT 5SGU 5SGV 5SGW 5SGX 5SGY 5SGZ 5SH0 5SH1 5SH2 5SH3 5SH4 5SH5 5SH6 5SH7 5SH8 5SH9 5SHA 5SHB 5SHC 5SHD 5SHE 5SHF 5SHG 5SHH 5SHI 5SHJ 5SHK 5SHL 5SHM 5SHN 5SHO 5SHP 5SHQ 5SHR 5SHS 5SHT 5SHU 5SHV 5SHW 5SHX 5SHY 5SHZ 5SI0 5SI1 5SI2 5SI3 5SI4 5SI5 5SI6 5SI7 5SI8 5SI9 5SIA 5SIB 5SID 5SIE 5SIF 5SIG 5SIH 5SII 5SIJ 5SIK 5SIL 5SIM 5SIN 5SIO 5SIP 5SIQ 5SIR 5SIS 5SIT 5SIU 5SIV 5SIW 5SIX 5SIY 5SIZ 5SJ0 5SJ1 5SJ2 5SJ3 5SJ4 5SJ5 5SJ6 5SJ7 5SJ8 5SJ9 5SJA 5SJB 5SJC 5SJD 5SJE 5SJF 5SJG 5SJH 5SJI 5SJJ 5SJK 5SJL 5SJM 5SJN 5SJO 5SJP 5SJQ 5SJR 5SJS 5SJT 5SJU 5SJV 5SJW 5SJX 5SJY 5SJZ 5SK0 5SK1 5SK2 5SK3 5SK4 5SK5 5SK6 5SK7 5SK8 5SK9 5SKA 5SKB 5SKC 5SKD 5SKE 5SKF 5SKG 5SKH 5SKI 5SKJ 5SKK 5SKL 5SKM 5SKN 5SKO 5SKP 5SKQ 5SKR 5SKS 5SKT 5SKU 5SKV 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6KO0 6KO1 6KZE 6MSA 6MSC 7BPI 7QPF 7QPM 7QPQ 7QPV 7QQ4 8DI4 8XV3 9JA8	1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		Response To Xenobiotic Stimulus Anterior Neural Tube Closure Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Luteolysis Glial Cell Apoptotic Process Response To Ionizing Radiation Phospholipase A2 Activator Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component RRNA Metabolic Process Pwp2p-containing Subcomplex Of 90S Preribosome Response To Anesthetic Protein-containing Complex Binding Death-inducing Signaling Complex DNA Topoisomerase Activity Response To Luteinizing Hormone Supercoiled DNA Binding Positive Regulation Of Pyroptotic Inflammatory Response Embryonic Cleavage Response To Cobalt Ion DNA Topological Change Response To Radiation Fibroblast Apoptotic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Activated T Cell Proliferation Interleukin-18-mediated Signaling Pathway Regulation Of Synaptic Vesicle Cycle Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation Positive Regulation Of Amyloid-beta Formation Death Receptor Binding Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Protein Poly-ADP-ribosylation DNA Binding, Bending Cellular Response To Gonadotropin Stimulus DNA Conformation Change SnoRNA Binding Response To Hormone Platelet Formation RRNA Transcription Execution Phase Of Apoptosis Positive Regulation Of Amyloid Precursor Protein Catabolic Process Neurotrophin Signaling Pathway Response To X-ray Response To Gonadotropin	Nucleoplasm Nucleus DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Double-strand Break Repair Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Macromolecule Metabolic Process DNA Repair Response To Ionizing Radiation Response To Radiation Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Response To X-ray Regulation Of Programmed Cell Death Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding MRNA Metabolic Process Cellular Response To Radiation Positive Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway DNA Metabolic Process DNA Topoisomerase Binding Nuclear Speck Cellular Developmental Process Positive Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-RNA Complex Assembly Protein Polyubiquitination
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