PDE10A

Gene Name		phosphodiesterase 10A
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction Blood Coagulation Regulation Of Protein Kinase A Signaling Regulation Of CAMP-mediated Signaling CGMP Catabolic Process
Pathways		Signaling by GPCR GPCR downstream signaling Platelet homeostasis G alpha (s) signalling events Nitric oxide stimulates guanylate cyclase cGMP effects
Drugs		Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE Tofisopam Triflusal
Diseases
GWAS		Conduct disorder (symptom count) ( 20585324) Thyroid hormone levels ( 23408906)
Protein-protein Interactions		3 interactors: CASP3 TOP1 WDR3
Entrez ID		10846
HPRD ID		17828
Ensembl ID		ENSG00000112541
Uniprot IDs		Q9Y233
PDB IDs		1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 4AEL 4AJD 4AJF 4AJG 4AJM 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4
Enriched GO Terms of Interacting Partners?		Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Embryonic Cleavage Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of B Cell Proliferation Apoptotic DNA Fragmentation Platelet Formation Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Maturation Of SSU-rRNA Release Of Cytochrome C From Mitochondria Apoptotic Nuclear Changes DNA Topological Change Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Ribosomal Small Subunit Biogenesis Programmed Cell Death Cell Death Death DNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Apoptotic Process Regulation Of B Cell Proliferation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of T Cell Proliferation Neuron Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Lymphocyte Homeostasis Apoptotic Mitochondrial Changes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Execution Phase Of Apoptosis Positive Regulation Of Neuron Death Negative Regulation Of Leukocyte Proliferation Cellular Nitrogen Compound Metabolic Process Circadian Regulation Of Gene Expression
Tagcloud ?		albeit baboons cerebellum discrepancies kinetics ma1 monkey monkeys mp multilinear negligible nonhuman penetrating periodicals phosphodiesterase primates radiolabeled radiometabolites radiotracer reliably rhesus scans seemingly suitability tracer unlabeled vt wiley