NTRK2 and BDNF

Number of citations of the paper that reports this interaction (PMID 9312147)
5

Data Source:
HPRD (in vitro, in vivo)

		NTRK2	BDNF
Gene Name		neurotrophic tyrosine kinase, receptor, type 2	brain-derived neurotrophic factor
Image
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density	Extracellular Region Extracellular Space Cytoplasm Synaptic Vesicle Cytoplasmic Membrane-bounded Vesicle Mitochondrial Crista Dendrite Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity	Neurotrophin TRKB Receptor Binding Growth Factor Activity
	Biological Process	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis	Ureteric Bud Development Behavioral Fear Response Response To Hypoxia Chronic Inflammatory Response Mitochondrial Electron Transport, NADH To Ubiquinone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Learning Circadian Rhythm Feeding Behavior Neuron Recognition Response To Light Intensity Response To Hormone Response To Auditory Stimulus Glutamate Secretion Response To Fluoxetine Response To Activity Dendrite Development Nerve Development Regulation Of Axon Extension Response To Food Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin A Response To Potassium Ion Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Axon Extension Neuron Projection Morphogenesis Inner Ear Development Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Response To Hyperoxia Regulation Of Excitatory Postsynaptic Membrane Potential Taste Bud Development Cellular Response To Tumor Necrosis Factor Cellular Response To Norepinephrine Stimulus Response To Anesthetic Dendrite Extension Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Waist-to-hip circumference ratio (interaction) ( 23192594)	Body mass index ( 22344221 23563607 19079260 20935630) Obesity ( 21708048 23563607) Smoking behavior ( 20418890) Weight ( 19079260)
Protein-Protein Interactions		29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB	14 interactors: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTRK2 SORT1
Entrez ID		4915	627
HPRD ID		02712	00214
Ensembl ID		ENSG00000148053	ENSG00000176697
Uniprot IDs		Q16620 Q548C2 Q5VWE5	P23560
PDB IDs		1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5	1B8M 1BND
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance	Signaling Cell Surface Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Cellular Response To Stimulus Signal Transduction Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Catalytic Activity Anatomical Structure Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Development Response To External Stimulus Locomotion Multicellular Organismal Development Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Nitric-oxide Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Phosphorylation Response To Stress Negative Regulation Of Calcium Ion Transport Neurotrophin Signaling Pathway Response To Abiotic Stimulus
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
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