NTRK2 and NTF3

Number of citations of the paper that reports this interaction (PubMedID 8621424)
0

Data Source:
HPRD (in vivo)

		NTRK2	NTF3
Description		neurotrophic receptor tyrosine kinase 2	neurotrophin 3
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor Receptor Activity	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Neurotrophin Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity
	Biological Process	Vasculogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Regulation Of Metabolic Process Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Retina Development In Camera-type Eye Long-term Synaptic Potentiation Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis	Positive Regulation Of Receptor Internalization Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Nerve Development Positive Regulation Of Cell Migration Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		PIP3 activates AKT signaling NGF-independant TRKA activation Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK2 (TRKB) signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K
Drugs		Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases		Neuroblastoma
GWAS		Birth weight ( 24950379) Body mass index ( 25760438 28892062) Body size at age 10 ( 32376654) Gout (normal type) ( 32238385) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)	Blood protein levels ( 30072576) Insomnia ( 29520036)
Interacting Genes		35 interacting genes: AP1B1 BDNF DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8	7 interacting genes: BDNF LRP1 MEOX2 NTRK1 NTRK2 NTRK3 SORT1
Entrez ID		4915	4908
HPRD ID		02712	01219
Ensembl ID		ENSG00000148053	ENSG00000185652
Uniprot IDs		A0A8I5KR47 A0A8I5KUZ1 A0A8I5KZB7 A0A8J8YUT9 Q16620 Q548C2 Q5VWE5	P20783
PDB IDs		1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9 8OYD	1B8K 1BND 1NT3 3BUK
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Nerve Growth Factor Signaling Pathway Neurotrophin TRKA Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Response To Growth Factor Regulation Of Protein Localization Cell Projection Organization Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Intracellular Signal Transduction Cytosol Nerve Growth Factor Receptor Binding Response To Epidermal Growth Factor Insulin Receptor Binding Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Ephrin Receptor Binding Negative Regulation Of Developmental Process Signaling Adaptor Activity Modulation Of Chemical Synaptic Transmission Regulation Of Cell Population Proliferation Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cellular Localization Neuron Projection Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of PERK-mediated Unfolded Protein Response Cell Projection Morphogenesis Regulation Of ERK1 And ERK2 Cascade Endosome Membrane	Neurotrophin Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Synapse Assembly Nerve Growth Factor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Junction Assembly Mechanoreceptor Differentiation Nerve Growth Factor Receptor Activity Positive Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synapse Assembly Receptor Complex Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Nerve Growth Factor Binding Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Positive Regulation Of Axonogenesis Regulation Of Synapse Organization GPI-linked Ephrin Receptor Activity Early Endosome Positive Regulation Of Cell Projection Organization Action Potential Propagation Neuronal Action Potential Propagation Axon Regulation Of Neuron Projection Development Regulation Of Nervous System Development Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Circadian Rhythm Regulation Of Axonogenesis Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Neuron Apoptotic Process Nervous System Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Neurogenesis Regulation Of Neuron Apoptotic Process Rhythmic Process Cellular Response To Growth Factor Stimulus Nerve Development Positive Regulation Of Multicellular Organismal Process Endosome Membrane
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