NTRK2 and NTF3

Number of citations of the paper that reports this interaction (PMID 8621424)
8

Data Source:
HPRD (in vivo)

		NTRK2	NTF3
Gene Name		neurotrophic tyrosine kinase, receptor, type 2	neurotrophin 3
Image
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density	Extracellular Region Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity	Receptor Binding Neurotrophin P75 Receptor Binding Growth Factor Activity Chemoattractant Activity Nerve Growth Factor Binding
	Biological Process	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis	Activation Of MAPK Activity Positive Regulation Of Receptor Internalization Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Neuromuscular Synaptic Transmission Nervous System Development Glial Cell Fate Determination Axon Guidance Brain Development Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Epidermis Development Nerve Development Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Mechanoreceptor Differentiation Myelination Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Enteric Nervous System Development Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB	5 interactors: BDNF MEOX2 NTRK1 NTRK2 NTRK3
Entrez ID		4915	4908
HPRD ID		02712	01219
Ensembl ID		ENSG00000148053	ENSG00000185652
Uniprot IDs		Q16620 Q548C2 Q5VWE5	P20783
PDB IDs		1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5	1B8K 1BND 1NT3 3BUK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance	Mechanoreceptor Differentiation Cellular Response To Nerve Growth Factor Stimulus Circadian Rhythm Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Neurogenesis Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Axonogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Response To Auditory Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Response To Mechanical Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamate Secretion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Modification Process Learning Or Memory Activation Of Adenylate Cyclase Activity Negative Regulation Of Cell Death Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Neuron Death Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Epithelium Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Electrical Stimulus Organ Development Positive Regulation Of Protein Metabolic Process
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2
Tagcloud (Intersection) ?