NTRK2 and KIDINS220

Number of citations of the paper that reports this interaction (PubMedID 15167895)
43

Data Source:
HPRD (in vitro, in vivo)

		NTRK2	KIDINS220
Description		neurotrophic receptor tyrosine kinase 2	kinase D interacting substrate 220
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Cell Projection Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Synapse Perinuclear Region Of Cytoplasm	Endosome Late Endosome Cytosol Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor Receptor Activity	Protein Binding Protein Kinase Regulator Activity PDZ Domain Binding
	Biological Process	Vasculogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Regulation Of Metabolic Process Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Cell Differentiation Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Retina Development In Camera-type Eye Long-term Synaptic Potentiation Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis	In Utero Embryonic Development Nervous System Development Positive Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		PIP3 activates AKT signaling NGF-independant TRKA activation Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5	ARMS-mediated activation ARMS-mediated activation RND2 GTPase cycle RND1 GTPase cycle
Drugs		Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases		Neuroblastoma
GWAS		Birth weight ( 24950379) Body mass index ( 25760438 28892062) Body size at age 10 ( 32376654) Gout (normal type) ( 32238385) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)	Alcoholic chronic pancreatitis ( 28754779) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32109663) Neutrophil count ( 21507922) Skin aging measurement ( 31522824) Waist-hip ratio ( 28552196)
Interacting Genes		35 interacting genes: AP1B1 BDNF DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8	12 interacting genes: CDC73 CRKL FHL3 KRT34 MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1 SEPTIN5
Entrez ID		4915	57498
HPRD ID		02712	17235
Ensembl ID		ENSG00000148053	ENSG00000134313
Uniprot IDs		A0A8I5KR47 A0A8I5KUZ1 A0A8I5KZB7 A0A8J8YUT9 Q16620 Q548C2 Q5VWE5	A0A8I5QJC0 Q9ULH0
PDB IDs		1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9 8OYD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Programmed Cell Death Signal Transduction Regulation Of Signal Transduction Nerve Growth Factor Signaling Pathway Neurotrophin TRKA Receptor Binding Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Response To Growth Factor Regulation Of Protein Localization Cell Projection Organization Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Intracellular Signal Transduction Cytosol Nerve Growth Factor Receptor Binding Response To Epidermal Growth Factor Insulin Receptor Binding Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Ephrin Receptor Binding Negative Regulation Of Developmental Process Signaling Adaptor Activity Modulation Of Chemical Synaptic Transmission Regulation Of Cell Population Proliferation Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cellular Localization Neuron Projection Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of PERK-mediated Unfolded Protein Response Cell Projection Morphogenesis Regulation Of ERK1 And ERK2 Cascade Endosome Membrane	Neurotrophin Binding Neurotrophin Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Circadian Rhythm Cellular Developmental Process Positive Regulation Of Neuron Projection Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Signal Transduction Response To Nerve Growth Factor Nerve Growth Factor Binding Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Neuron Projection Development GPI-linked Ephrin Receptor Activity Positive Regulation Of Synapse Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Postsynaptic Specialization Assembly Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Action Potential Propagation Neuronal Action Potential Propagation Cell Death Programmed Cell Death Rhythmic Process B Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Nervous System Development System Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Positive Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization
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