ZNF274 and NGFR

Number of citations of the paper that reports this interaction (PMID 10545116)
23

Data Source:
HPRD (in vivo, in vitro)

		ZNF274	NGFR
Gene Name		zinc finger protein 274	nerve growth factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Generic Transcription Pathway	Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		1 interactors: NGFR	45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274
Entrez ID		10782	4804
HPRD ID		05682	01197
Ensembl ID		ENSG00000171606	ENSG00000064300
Uniprot IDs		Q96GC6	P08138
PDB IDs			3EWV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hair Follicle Development Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Hair Follicle Development Membrane Protein Intracellular Domain Proteolysis Regulation Of Glucose Import In Response To Insulin Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Hair Cycle Detection Of Temperature Stimulus Regulation Of Odontogenesis Hair Follicle Morphogenesis Membrane Protein Proteolysis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Morphogenesis Skin Morphogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Glucose Import Regulation Of Epidermis Development Positive Regulation Of Axonogenesis Circadian Regulation Of Gene Expression Regulation Of Cellular Response To Insulin Stimulus Hair Follicle Development Hair Cycle Process Nerve Development Regulation Of Fibroblast Proliferation Regulation Of Glucose Transport Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cellular Response To Growth Factor Stimulus Hair Cycle Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Circadian Rhythm Detection Of Abiotic Stimulus Regulation Of Organ Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Response To Temperature Stimulus Negative Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Glucose Homeostasis Regulation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Skin Development	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		116hg 15q11 demethylation dimethylation disrupts feet h3k4me2 h3k9 h3k9me3 hands hydroxymethylcytosine hyperphagia hypogonadism hypotonia imprinting ipscs maternally methylcytosine paternal pluripotent prader pws q13 repress setdb1 silent snord116 snornas willi	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?		116hg 15q11 demethylation dimethylation disrupts feet h3k4me2 h3k9 h3k9me3 hands hydroxymethylcytosine hyperphagia hypogonadism hypotonia imprinting ipscs maternally methylcytosine paternal pluripotent prader pws q13 repress setdb1 silent snord116 snornas willi	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?