DCTN6 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		DCTN6	HSPB2
Description		dynactin subunit 6	heat shock protein family B (small) member 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Cytoskeleton	Nucleus Cytoplasm Cytosol
	Molecular Function	Dynein Complex Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Mitotic Spindle Organization	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Breast size ( 27182965) Serum alkaline phosphatase levels ( 33547301)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA RSPH1	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		10671	3316
HPRD ID		09907	03712
Ensembl ID		ENSG00000104671	ENSG00000170276
Uniprot IDs		O00399	A8KAH6 Q16082
PDB IDs		3TV0	6F2R
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Signal Transduction Response To Norepinephrine Response To Copper Ion Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Chromatin Organization Reproductive Process Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Response To Stress Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Interleukin-1 Beta Production Small Molecule Biosynthetic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Schwann Cell Differentiation Virus Receptor Activity Cyclin B1-CDK1 Complex Symbiont Entry Into Host Cell Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Cyclin-dependent Protein Kinase Activity Somatic Muscle Development Quinolinate Biosynthetic Process Positive Regulation Of Chronic Inflammatory Response Kynurenic Acid Biosynthetic Process	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?