DNMBP and CYFIP2

Number of citations of the paper that reports this interaction (PubMedID 14506234)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DNMBP	CYFIP2
Description		dynamin binding protein	cytoplasmic FMR1 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Cytosol Cytoskeleton Cell-cell Junction Nuclear Body Synapse Anchoring Junction Presynapse	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding
	Biological Process	Regulation Of Cell Shape Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly	Cell Morphogenesis Apoptotic Process Cell Adhesion Axon Guidance Cell Projection Assembly Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Cell-cell Adhesion Regulation Of Postsynapse Assembly
Pathways		CDC42 GTPase cycle	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Stent thrombosis in response to clopidogrel treatment ( 32472697)	Alanine aminotransferase levels ( 33547301) Asthma ( 31959851 32296059 34103634) Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		21 interacting genes: ACTA1 ARHGAP17 BUB1B CDC42 CNN1 CYFIP2 DBN1 DNM1 ENAH EVL FASLG HSPA1B KHDRBS1 NCKAP1 RAC1 RAPH1 UBC VASP WASF1 WASL WIPF2	22 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A
Entrez ID		23268	26999
HPRD ID		10918	07556
Ensembl ID		ENSG00000107554	ENSG00000055163
Uniprot IDs		A0A1B0GTX1 A0A1C7CYY6 B3KY33 Q6XZF7	B7Z8N7 E7EVJ5 Q96F07
PDB IDs		1UG1 1UHC 4CC2 4CC3 4CC4 4CC7 4GLM
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Lamellipodium Cytoskeleton Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Profilin Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Filopodium Neuron Projection Development Positive Regulation Of Protein Polymerization Actin Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cellular Component Organization Postsynapse SCAR Complex Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Polymerization Actin Filament-based Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cellular Component Organization Regulation Of Actin Filament Length Actin Cytoskeleton Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Cytoplasm Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Lamellipodium Assembly Axon Guidance Neuron Projection Guidance Cell Projection Regulation Of Cell Projection Assembly Actin Filament Polymerization Extracellular Exosome Positive Regulation Of Lamellipodium Organization	SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Actin Nucleation Lamellipodium Organization Lamellipodium Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Morphogenesis Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Cell Motility Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Postsynapse Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Actin Filament Organization Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Synapse Regulation Of Cell Projection Organization Translation Regulator Activity Positive Regulation Of Translation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Signaling Adaptor Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Signal Transduction Presynapse Positive Regulation Of Lamellipodium Organization Lamellipodium Assembly RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process MRNA 3'-UTR Binding
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