EXOC5 and THOC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EXOC5	THOC1
Description		exocyst complex component 5	THO complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Midbody	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	Protein Binding Small GTPase Binding	DNA Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Protein Localization To Plasma Membrane Membrane Fission Vesicle Tethering Involved In Exocytosis Epithelial Cell Apoptotic Process Non-motile Cilium Assembly	MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA Transport
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Chronotype ( 30696823) HDL cholesterol levels in HIV infection ( 33109212) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		41 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L C1orf216 CCDC102B CDH2 CREBBP CRYBB1 DEUP1 DNAAF4 EDRF1 ENO2 FGA FRMD6 HDDC3 HGS ICA1 IFT57 KIFC3 MAGEA3 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 THOC1 TNPO2 TTC23L TXLNB TXNL4A USP2	32 interacting genes: AGR2 AKAP9 CTAG1A CTAG1B DHX8 ESS2 EXOC5 EXOSC7 FRA10AC1 GPRASP3 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C PRC1 PRPF6 RABGEF1 RB1 REL SAP30BP SF3B2 SNW1 TADA2A TFIP11 TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		10640	9984
HPRD ID		07258	09498
Ensembl ID		ENSG00000070367	ENSG00000079134
Uniprot IDs		O00471	Q96FV9
PDB IDs			1WXP 7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		G Protein Activity GDP Binding Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Membrane GTPase Activity Early Endosome Membrane Regulation Of Endocytosis Insulin-responsive Compartment	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Spliceosomal Complex RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing Cyclin/CDK Positive Transcription Elongation Factor Complex U2-type Precatalytic Spliceosome
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